Postby Sophy » Sun Jul 16, 2017 6:04 am
There are quite a few posts by Maia about this if you want to look them up, she has many links to information about it and I have posted about it too, but Maia is the most knowledgeable.
Basically it is a trial combining low dose capecitabine (oral 5fu, also called xeloda) with celecoxib, an arthritis painkiller. It is testing whether the addition of celecoxib to capecitabine both enhances the tumour destroying effect of the chemo whilst also decreasing the side effects.
It seems to work best on very low tumour burden, and it doesn't work for everyone, members here have had progression on it and later died. I started it in August 2014 after 3 lung laser surgeries in Europe removing all visible mets. All my scans have been clear since then.
As my tumours have never been detectable with blood markers CEA or CA19-9 my oncologist says there is no way to know if I have new mets growing before they are large enough to see on CT - about 5mm.
So, as my quality of life is very good on ADAPT, my oncologist and I agree that I should not risk stopping ADAPT and then having tumour growth which could not be controlled - so I will continue to take it indefinitely until we have more information from the ADAPT trial and other trials like immunotherapy which could give a better chance of a cure and not just a disease control.
Hope that this helps
Sophy
dx T3N1M0 Feb 2011 when children age 11, 7 and 2
Xeloda/rad March 11, LAR June 11 temp ileo
Xelox 6 rounds, NED
Lung mets Oct 13
Laser surgery Germany Jan 14. 3 mets left lung.
Laser surgery UK Jun and Aug 14 one met each lung, NED
Aug 14 Started Xeloda and Celebrex (ADAPT)
June 20 CT shows nodule, bronchoscopy confirms is scar tissue, still NED
Dec 20 stopping Xeloda continue celebrex, cimetedine
Aug 21,March 23 scans show still NED
March 2023 CURED - discharged from Oncology, no more scans or follow up