I just read a recent abstract of a paper found in the recent Science Signaling entitled:
Inflammation helps tumors evade immune detection see: http://stke.sciencemag.org/content/9/45 ... id=1064306
in this paper they demonstrate in mouse and other models that Inflammation in the tumor microenvironment has a direct effect on the abundance of the immune checkpoint ligand PD-L1 on the surface of tumor cells. They go on to determine that this is through a mechanism involving NF-kB activation which in turn may be correlated with stability of PD-L1. Inhibiting NF-kB via use of Curcumin at levels lower than those needed to kill a tumor, might still be clinically effective because it would inhibit NF-kB and reduce PD-L1 abundance.
Enjoy,
GrouseMan