ronswife wrote:I have a question on the TIL trials. How long does it take to actually get into the trials once you apply? Are there any steep fees? A lot of red tape?
I can tell you that the TIL trial at NIH will cost almost nothing for the patient, but travel for caregivers is not reimbursed. Any of the TIL trials will take several months. First step is to send all of your medical records and recent scans. They will be looking for a large (bigger than 1.5cm), easily resectable tumor. We had good results with two taken from the lung, but they can get them from other places as long as the surgery isn’t difficult. If they want to see you, they will invite you for a screening within a couple of weeks (they don’t normally pay travel for this visit). Then schedule surgery a couple weeks later. Then the waiting starts. If everything goes well, about 3 months after surgery, they will call you back for a month of in-patient treatment. The treatment includes a week of chemotherapy, the cell infusion, and a day or two of cytokine infusions, followed by a couple of weeks of waiting for your immune system to recover. After they let you go, they will want you to return every 6 weeks or so to check the shrinkage of the tumors. If everything shrinks and continues shrinking, they will reduce the visits to quarterly after about six months.
Also affecting timing, they require a 4 week chemo wash-out period before surgery and before cell infusion, so you need to consider whether that will be too long off chemo for him.
I think that M.D. Anderson plans a similar trial, but I don’t know anything about criteria, timing, or costs.