Immunotherapy Trial: Patients WITH Brain Metastases

[DK37]

FOR PATIENTS WITH BRAINS METASTASES

Many trials exclude patients with brain metastases. This new trial opening up (Boston, NCT02886585) is specifically recruiting patients WITH brain metastases. The experimental treatment will be a mixture of SBRT + PD1. It is open to both MSS and MSI-high CRC patients.

https://clinicaltrials.gov/ct2/show/NCT ... 585&rank=1

Cheers,
-DK

[CRguy]

Thanks once again for this important news, bro' !

I know there are folks here and on FB which this may impact and your updates here are ALWAYS the first thing I look for
... and further thanks for keeping your ongoing sticky current = a great resource !

Cheers and Harmony coming atcha'
CR on the Journey

[nomoretacos]

Is it okay if I ask a question regarding brain metastases? if it doesnt really belong here I can post a new thread

People who have CT scans after first being diagnosed and those who are NED receiving follow up scans, do they usually include scans of the brain, or just chest/abdomen? I raised the question of brain metastases with my onc during our first meeting and she brushed it off really quickly saying brain metastases are really rare

[DK37]

Is it okay if I ask a question regarding brain metastases? if it doesnt really belong here I can post a new thread

People who have CT scans after first being diagnosed and those who are NED receiving follow up scans, do they usually include scans of the brain, or just chest/abdomen? I raised the question of brain metastases with my onc during our first meeting and she brushed it off really quickly saying brain metastases are really rare

A good question. Brain mets are relatively rare in CRC (off the top of my head I think occur in 3-5% of Stage IV CRC cases, so much lower likelihood than other anatomical sites but certainly not incredibly rare, I have had a number of friends with them). It is standard of care to not include brain scans as a part of normal monitoring.

For those with active Stage IV disease, I have heard second-hand that MDA is including a brain scan check of patients with active lung mets (at 2 year mark?) but I do not know that info first-hand. In my anecdotal observations, it has appeared they are often discovered via a brain scan ordered due to 1.) A significant rise in CEA without any obvious cause seen in the standard chest-pelvis CT-scans 2.) Neurological clinical symptoms

-DK

[Sams wife]

Nomoretacos. My husband had a spot on his nose that went away during chemo. It has since came back. I'm not sure if it was just that or him falling & hitting head a few times, but they started scanning his head. I think they still are. Will see this month !

[nomoretacos]

Thanks guys for answering my question, makes me feel a bit more at ease knowing it is standard practice not to scan the brain unless there is a reason