Mastan wrote:I have done Xeloda in combination with Celebrix, that is the ADAPT Protocol the Dr. Lin uses at the Seatle Cancer Care Alliance. Xeloda is 2 weeks on 1 week off. For a month or so side effects were not too problematic. Then the hand/foot syndrome kicked in and things got nasty. A lot of skin peeling off, redness, and swelling. I ended up with an infection in one of my big toes that had to be treated with minor surgery by a podiatrist. Everyone reacts differently to the chemo poison so you may want to give it a try and see how it plays out. I am back on the infused 5-FU and the hand/foot syndrome is just a distant bad memory.
WriterGirl1969 wrote:Thank you everyone. This is wonderful, and very appreciated. I am trying to take everything into consideration, and this really helps. I really am feeling strongly that I want to at least try the Xeloda. I feel as though keeping my morale up is extremely important, and the idea of not having to contend with IV's and hours out of work and in a chair getting infused will help with that. I can be extremely anal about doing things, and feel I could keep up with the water, B6 and creams that can help alleviate the hand/foot syndrome. And if not, well we can always switch it up if needed. I will arm myself with all of this information, and again, thank you *SO* much for all of the information.
Lund5505 wrote:I have done both folfox and xeloda alone. You will need to do the 3 hours for the premeds and oxy regardless of 5fu or xeloda.
The biggest difference on my opinion is that with the xeloda you do not need to make an additional trip to the infusion center for disconnect. I also had a lot of difficulty sleeping with the pump between the humming and the needle in my chest and getting tangled in the cords I was strung out from lack of sleep by disconnect day. I seemed to have less fatigue with the xeloda than the 5fu but to be fair my 5fu was with the oxy and the xeloda was not. I had mild hand foot syndrome from both. Not really painful just seemed like the skin on the bottom of my feet got thicker. I would try the xeloda first and switch to 5fu if needed.
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