New MSS CRC Phase 1 Trial: PF-06671008 (P-cadherin targeting)

[DK37]

There is a new CRC Phase 1 trial just added to clinicaltrials .gov
NCT02659631 for an experimental drug called "PF-06671008" which targets CRC tumors with the P-cadherin cell marker.
https://clinicaltrials.gov/ct2/show/NCT ... 631&rank=1

There are specifically recruiting for CRC, including MSS. You would have to call for locations, not listed yet.

It is a Phase 1 trial so they will be starting with low dose & looking for safety in addition to efficacy.

Pfizer hasn't publicly released what exactly the drug is (as far as I can tell) but looking at its immune related exclusion criteria & their recent publication history, I think there is good chance it is a P-cadherin x CD3 bifunctional DART which is a form of immunotherapy - but that is just an educated guess at this point.

They presented a P-cadherin x CD3 bifunctional DART at a cancer conference last Spring http://cancerres.aacrjournals.org/conte ... ement/2476

If it is a DART, that strategy basically physically pulls a T-Cell right up against a tumor cell expressing the target (in this case “P-cadherin”) - once it is pulled next to it, tumor cell killing should hopefully commence. If you are familiar with the clinical trial drug “MGD007” this is the same concept just using a different cancer cell marker. Not as subtle a solution as some other immunotherapy options but... with an immunologically cold tumor like MSS-CRC, some brute force may be needed.

I'll update if it becomes confirmed what exactly PF-06671008 is -- as I said, just an educated guess at this point but it is probably their DART.

Cheers,
-DK

[jortego128]

DK, have you or anyone else heard how the trials are going with the MGD-007? There was that young woman and mother of some young children who had the blog (dont recall her name atm) that seemed to be responding to it, but I havent heard anything in a while. Hope she is doing OK.

[DK37]

DK, have you or anyone else heard how the trials are going with the MGD-007? There was that young woman and mother of some young children who had the blog (dont recall her name atm) that seemed to be responding to it, but I havent heard anything in a while. Hope she is doing OK.

Hi Jortega, she was stable on it for anumber of months, but then had progression. Dose escalation & frequency have continued to identify the maximum tolerated dose. I have not heard from people on higher doses, so I do not know if it is working or not... Maybe an update at ASCO?

-DK