MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

[DK37]

Here is another experimental Phase 1 clinical trial that I find scientifically interesting - so I am keeping a close eye on - another second strategy to attempt to make MSS-CRC "cold" tumors "hot". This one is exclusively for MSS patients & exclusively at Johns Hopkins.

It uses two "epigenetic" drugs in combination with a PD-1 inhibitor. In CRC animal models the drugs remove immunosuppressive signals - so enhance the power of immunotherapies such as PD-1 inhibitors. At least in animal models...

There is no CRC human clinical trial data released yet.

https://clinicaltrials.gov/ct2/show/NCT ... 172&rank=1

Preclinical paper it is based on: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136565/

-DK

[ieowi]

do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.

[DK37]

do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.

A long shot but in life in general I always follow the adage it never hurts to ask!

-DK

[ieowi]

do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.

A long shot but in life in general I always follow the adage it never hurts to ask!

-DK

[Ceebo]

Thanks once again for this information! Sounds like an interesting trial. So thankful that there are new trials becoming available specifically for people who are MSS. I was feeling like there weren't any other options for my DH and I was feeling a bit frustrated. This gives us some hope for the future.
--Cindie

[ieowi]

FYI, Msi-low arm of this trial is closed