Paul, if immediate ablation is not an option (that NIH trial I've mentioned on PM
http://clinicalstudies.info.nih.gov/cgi ... -0079.html or any other option) and you're considering going for something systemic immediately... you may want to check
1. this immunotherapy trial, because it's
aimed mainly to KRAS mutant CRC (which is the case here, right):
A Phase 1b Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic Solid Tumors http://clinicaltrials.gov/ct2/show/study/NCT01988896Tracie is already a patient at MSK, where it is recruiting... and you have a nearer location recruiting (Nashville, Tennessee; my guess is that is teh Vanderbilt-Ingram Cancer Center)
Discussed here:
viewtopic.php?f=1&t=454852. This other NIH immunotherapy trial: it's not for a checkpoint inhibitor but for the other kind of
personalized immunothearapy: Adoptive Cell Therapy (immune cells are removed from a patient, genetically modified or treated with chemicals to enhance their activity, and then re-introduced into the patient with the goal of improving the immune system’s anti-cancer response). it's the kind of thing that for now only the NIH or some big centers can do... no a pharmaceutical company, so there are few locations for that.
A Phase II Study Using Short-Term Cultured, CD8+-Enriched Autologous Tumor-infiltrating Lymphocytes Following a Lymphocyte Depleting Regimen in Metastatic Digestive Tract Cancers http://www.clinicaltrials.gov/ct2/show/NCT01174121The outcomes for blood cancers have been spectacular and for solid tumours, the results are just starting. You can read about one outcome (solid tumour) from that trial here: New York Times, May 8 2014:
http://www.nytimes.com/2014/05/09/healt ... &smv2&_r=1(We discussed that here:
viewtopic.php?f=1&t=46555 )