October 01, 2013 at 7:41 PM "The second pathway, revealed by our results today, is more involved in metastasis, by influencing the platelets in the bloodstream. Although speculative, it may be that the interaction of platelets with HLA positive tumour cells circulating in the blood promotes the metastatic potential of these cells. Aspirin interferes with this interaction, thereby decreasing the risk of metastatic disease and colon cancer-related death."
Aspirin's ability to slow metastasis may be linked to its effect on platelets, the clotting bodies in the blood, said the scientists. The role of platelets in promoting cancer spread in mice was reported more than 40 years ago. Rothwell said the effect of aspirin on the spread of cancer was unique and might be useful in treatment. “Previously, no drug has ever been shown to reduce metastasis as a specific effect,” he said. “It opens up a completely new therapeutic area.”
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