Does anyone know if Lynch Syndrome and Signet Ring cell are related? They both appear to be somewhat rare? Does anyone know the percentages?
I'm trying to figure out what our oncologist said today about the first step. He mentioned something about microsatellite instability negative (I know he said negative, but not sure if in relation to the microsatellites). He said that 95% of people with Lynch would test positive for this thing so that is a good sign we don't have Lynch which would be a great relief since we have young children. He said there is another test (path related to staining perhaps) and I think I'd like to push for the blood test if that is all it takes for genetic testing. Hoping the insurance will cover it based on my husband's young age (41). No other family history for him thankfully.
About signet. I asked today and they confirmed that the pathology report would have indicated signet ring cell if it was there. Do you all agree that is standard protocol for a pathologist regardless of whether they are at a large facility? They do have a cancer center at our hospital which makes me thing they would know what is important to notate in cancer cases.
Really liking our oncologist. He is positive and has an easy personality but answers all of our questions and is open to of course consulting with another oncologist at UCSF who of course has to be on sabbatical until January. In the mean time, I am happy with our plan and am hoping and praying for good results from Folfox7 plus Avastin on the peritoneal mets. Oncologist says he has had good response in the past and I see no reason for him to give us false hope.
Best to you all. I have been reading and learning so much for all of you and have to think that if the docs had access to all of these different cases they would learn a great deal more about how to beat this beast. Thank you for your help and support.
Serena