Postby catstaff » Fri Mar 26, 2021 8:34 am
It seems plausible that long-term chemo will wear one down, but it does appear that FOLFIRI is feasible over the (relatively) long term, which isn't the case for all chemos.
Kandj, I assume your husband is wild-type for KRAS and BRAF, is that correct? His endurance sounds amazing.
Irinotecan is the cause of any hair loss. Perhaps it's used at a higher dose when it's combined with Xeloda as compared to FOLFIRI. 5FU/Xeloda/capecitabine causes little to no hair loss by itself.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-