beach sunrise wrote:Hi, been researching CEA and Iron spikes. I found two papers talking about the APC gene and turning on the Wnt pathway. Does anyone know anything about this? Is there a test to find out about the gene and pathway? Any info at all would be so helpful.
All else on bloodwork looks good.
""What is the role of the Wnt pathway in colon cancer?
Wnt is a very complicated pathway that is particularly important in colon cancer, and is present in over 95% of tumors. The reason this pathway is complex is because the regeneration of the intestinal mucosum is driven by the colon stem cells; in order for the intestinal mucosa to rejuvenate every 24 hours, it first undergoes proliferation and then differentiation to result in a mature intestinal mucosa. The Wnt pathway is one of the most important pathways involved in this process. Obviously, if the Wnt pathway is altered -- and particularly the proliferation pathway is changed -- colon cancer can develop. ""
Colorectal cancer: the APC-lncRNA link
The adenomatous polyposis coli (APC) tumor suppressor gene was first discovered over 25 years ago as the gene that is mutated in familial adenomatous polyposis (FAP), a hereditary cancer syndrome characterized by the development of a large number of adenomas, some of which eventually progress to cancer. The APC gene is also mutated in the vast majority of sporadic colorectal cancers (CRCs), and APC mutations are observed in the earliest premalignant lesions. For these reasons, APC is believed to play crucial roles in the normal homeostasis of the colonic epithelium, and mutation of the APC gene is thought to be the first step in the series of genetic changes required in the progression from normal colorectal epithelium to the fully malignant state .
Green Tea wrote:
In addition to this, members Maia and Grouseman, separately, posted a dozen or more messages referencing this topic also in the 2014 timeframe.
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