Wnt pathway

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beach sunrise
Posts: 400
Joined: Thu Mar 05, 2020 7:14 pm

Wnt pathway

Postby beach sunrise » Sat Jan 23, 2021 1:29 am

Hi, been researching CEA and Iron spikes. I found two papers talking about the APC gene and turning on the Wnt pathway. Does anyone know anything about this?
Is there a test to find out about the gene and pathway? Any info at all would be so helpful.
All else on bloodwork looks good.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

User avatar
Green Tea
Posts: 340
Joined: Mon Oct 24, 2016 10:48 am

Re: Wnt pathway

Postby Green Tea » Sat Jan 23, 2021 1:44 pm

beach sunrise wrote:Hi, been researching CEA and Iron spikes. I found two papers talking about the APC gene and turning on the Wnt pathway. Does anyone know anything about this? Is there a test to find out about the gene and pathway? Any info at all would be so helpful.
All else on bloodwork looks good.

  1. "Does anyone know anything about this?

    I know next to nothing about this subject, but there are four members here who have posted comments about this pathway.

    The first member to post on this subject was Laurettas (January 9, 2013) who posted a message entitled, "Interesting article on wnt pathway"
    ""What is the role of the Wnt pathway in colon cancer?

    Wnt is a very complicated pathway that is particularly important in colon cancer, and is present in over 95% of tumors. The reason this pathway is complex is because the regeneration of the intestinal mucosum is driven by the colon stem cells; in order for the intestinal mucosa to rejuvenate every 24 hours, it first undergoes proliferation and then differentiation to result in a mature intestinal mucosa. The Wnt pathway is one of the most important pathways involved in this process. Obviously, if the Wnt pathway is altered -- and particularly the proliferation pathway is changed -- colon cancer can develop. ""

    Ref   https://www.onclive.com/view/five-wnt-related-questions-for-heinz-josef-lenz-md-facp

    https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=38954&p=277774#p277774

    Later, member Skypup posted a message on this topic on Dec 8, 2014.

    In addition to this, members Maia and Grouseman, separately, posted a dozen or more messages referencing this topic also in the 2014 timeframe.
    .
  2. "Is there a test to find out about the gene and the pathway?

    ColoNext®Test for mutations in APC gene
    https://www.ncbi.nlm.nih.gov/gtr/tests/560523/

    Info on APC regulator of WNT signaling pathway
    https://www.ncbi.nlm.nih.gov/gtr/genes/324/
    .
  3. Any info at all would be so helpful
    Colorectal cancer: the APC-lncRNA link
    The adenomatous polyposis coli (APC) tumor suppressor gene was first discovered over 25 years ago as the gene that is mutated in familial adenomatous polyposis (FAP), a hereditary cancer syndrome characterized by the development of a large number of adenomas, some of which eventually progress to cancer. The APC gene is also mutated in the vast majority of sporadic colorectal cancers (CRCs), and APC mutations are observed in the earliest premalignant lesions. For these reasons, APC is believed to play crucial roles in the normal homeostasis of the colonic epithelium, and mutation of the APC gene is thought to be the first step in the series of genetic changes required in the progression from normal colorectal epithelium to the fully malignant state .
    Ref: https://www.jci.org/articles/view/125985

User avatar
beach sunrise
Posts: 400
Joined: Thu Mar 05, 2020 7:14 pm

Re: Wnt pathway

Postby beach sunrise » Sat Jan 23, 2021 5:15 pm

Thank you so much, Green Tea! I didn't search that far back on the forum :)
Trying to get all my ducks in a row for discussion with dr on Tues about this and a few other things.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

User avatar
GrouseMan
Posts: 854
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Wnt pathway

Postby GrouseMan » Mon Jan 25, 2021 10:40 am

Green Tea wrote:
In addition to this, members Maia and Grouseman, separately, posted a dozen or more messages referencing this topic also in the 2014 timeframe.



I'll have to go back and review what Maia and I said on this topic 6+ years ago. Wnt is not an easy drug target from what I remember. A couple of other members of the anticancer research group of which I was a part was looking at WNT inhibitors back about 18 years ago I believe, but not having a lot of luck with a druggable compound. Since 2014 - am sure a lot on new stuff has been found on the topic. I've just not kept up with it. Haven't heard from Maia in a long time. Miss her and DK quite a bit.

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

User avatar
beach sunrise
Posts: 400
Joined: Thu Mar 05, 2020 7:14 pm

Re: Wnt pathway

Postby beach sunrise » Mon Jan 25, 2021 6:13 pm

Research is hard to find for sure.
I did find a paper that said everolimus (mTOR inhibitor) plus genistein also has good results against Wnt in the small studies. I'll take it, goodness.
If you run across anything please let me know. I am still digging for info over here.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"


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