My VEGF is way high after taking a chemical break that includes an Avastin break. I'm taking Honokiol and VascuStatin to target VEGF but I won't have more bloodwork for another 2-3 weeks so I can't tell you how well it worked. Maybe ask your ND about them. If you take one or both, know that they can cause loose stools so start slow and increase gradually. You might also consider picking up Eat to Beat Disease by William Li, MD. There's a good explanation of angiogenesis and foods that provide a natural defense against it.
Edited to add: if you go on Avastin, keep an eye on your BP, as others have noted. My BP was always very low all my life but after about 1 year on Avastin, it started to suddenly rise. I ended up going on a mild BP med that had to be increased 3 times. Also be more careful about injuries because Avastin will make you bleed more, plus it will take a lot longer to heal. If you need to have any elective surgery, I think you need to be off Avastin for 28 days because of the bleeding issue.
Nov-2009 Early stage CRC found during routine colonoscopy
2010, 2011, 2014 F/U colonoscopies, all clear
Jun-2016 CRC during routine follow up colonoscopy, surgery, Stage 4, KRAS, MSS, inoperable lung mets
Aug-2016-May-2018 Folfox, 5FU & Avastin, 5FU, Folfiri & Cyramza
Aug/Sep-2018 YAG laser surgeries (Germany), 11 nodules (9 mets) removed
Nov-2018 clean CT scan
Mar-2019 New lung nodules
Apr-2019 Nov-2020 Xeloda/Avastin, SBRT, continue Xeloda/Avastin
Dec-2020 Progression, considering all options