Chemo response after 3 cycles

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Markdale
Posts: 13
Joined: Wed Dec 02, 2020 4:45 pm

Chemo response after 3 cycles

Postby Markdale » Sat Dec 26, 2020 12:03 am

Hello everyone,

I was to get a ct guided biopsy of a lung nodule that made me stage 4. When they did the prescan there was only a hollow space where the suspect nodule should have been. I have 3 other nodules that showed no change and the radiologist who is associate professor level suspects they are not metastasis. He said the possibilities are the chemo has done it’s job after 3 rounds or it was never a metastasis just something that has occurred after a lung infection. The radiologist said he will go over my other scans in greater detail and write up a report as the pet scan was done with low resolution ct.

Has anyone had experience or stories of chemo (folfoxiri) that has worked so fast?

Has anyone had a similiar situation? Has chemo worked so quickly for anyone?
09/20:Diagnosed after colonoscopy for bleeding.
MRI and ct scan confirmed tumor at rectosigmoid junction aswell as lung nodules in right lower lobe (1X1.2cm) and right upper lobe (3X.5cm)
10/20: low anterior resection tumour t3n2m1 4 lymph nodes positive of 24. No ileostomy.
11/20: pet scan showed low to moderate uptake of glucose.
11/20: began folfoxiri..
12/20: ct lung biopsy of lung nodule to confirm metastasis

User avatar
beach sunrise
Posts: 356
Joined: Thu Mar 05, 2020 7:14 pm

Re: Chemo response after 3 cycles

Postby beach sunrise » Sat Dec 26, 2020 2:58 pm

Can't answer your questions but can comment "THATS AWESOME" chemo worked so well for you!!!
Merry Christmas for sure!!!
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug. Adding Everolimus soon.
MHL1+
PMS2+
MSH2+
MSH6+
POLD1
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

Rock_Robster
Posts: 529
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Chemo response after 3 cycles

Postby Rock_Robster » Sat Dec 26, 2020 7:55 pm

Mark that’s great news; if any chemo was going to do it then it would be FOLFOXIRI. I suppose if the lesions were small then it’s always possible. I guess the big question is, what happens now... watch and wait? Attempt to biopsy (maybe too small)? Repeat PET (may also be too small)?

Whatever the recommendation, it could be a good opportunity to get a second opinion on the scans too.
38M Australia
10/2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1, Dec-20: 2.3
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (CT/PET/MRI) - latest Dec 2020
07/20 Clear scope

Markdale
Posts: 13
Joined: Wed Dec 02, 2020 4:45 pm

Re: Chemo response after 3 cycles

Postby Markdale » Sun Dec 27, 2020 8:19 pm

Thank you, I will have to wait till I see have my next onc appointment. I’m hoping it was never a metastasis, if it was and the chemo destroyed it most likely means the other 3 are not metastasis because there has been no change.

This is the first bit of good news I got since they first found this during the colonoscopy.

Mark
09/20:Diagnosed after colonoscopy for bleeding.
MRI and ct scan confirmed tumor at rectosigmoid junction aswell as lung nodules in right lower lobe (1X1.2cm) and right upper lobe (3X.5cm)
10/20: low anterior resection tumour t3n2m1 4 lymph nodes positive of 24. No ileostomy.
11/20: pet scan showed low to moderate uptake of glucose.
11/20: began folfoxiri..
12/20: ct lung biopsy of lung nodule to confirm metastasis

Claudine
Posts: 460
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Chemo response after 3 cycles

Postby Claudine » Mon Dec 28, 2020 2:48 pm

Hi Mark,

In 2019, my husband had Folfori + Avastin for (among other things) numerous tiny lung lesions (up to 5mm but mostly 1-2mm). Most of them disappeared or shrank even more after a few cycles. His most recent scan (Dec 17) shows there are still several small nodules, up to 3mm in size, but they haven't changed in over a year so the onc thinks they're calcified/chemo killed them. Chemo is nasty stuff, but it can do the job, even with just a few cycles!
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 51
Scan 03/19: Multiple small lung nodules, now gone
PET 04/20 uptake by L4
L3-L4-L5 fusion surgery and partial corpectomy 05/20
Scan 12/17: nothing to report

Markdale
Posts: 13
Joined: Wed Dec 02, 2020 4:45 pm

Re: Chemo response after 3 cycles

Postby Markdale » Mon Dec 28, 2020 11:18 pm

Thank you.

I was reading an article about a study into folfoxiri conducted in Vietnam. It was only a small study of unresectable colorectal cancer, it showed approx 5% had a complete response to folfoxiri.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084041/
09/20:Diagnosed after colonoscopy for bleeding.
MRI and ct scan confirmed tumor at rectosigmoid junction aswell as lung nodules in right lower lobe (1X1.2cm) and right upper lobe (3X.5cm)
10/20: low anterior resection tumour t3n2m1 4 lymph nodes positive of 24. No ileostomy.
11/20: pet scan showed low to moderate uptake of glucose.
11/20: began folfoxiri..
12/20: ct lung biopsy of lung nodule to confirm metastasis


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