Vit D and immunotherapy

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plastikos
Posts: 351
Joined: Wed Jan 14, 2015 6:09 am

Vit D and immunotherapy

Postby plastikos » Tue Sep 15, 2020 11:32 pm

Question for everyone who’s on or has been on immunotherapy, specifically checkpoint inhibitors. Do you take Vit. D supplements or not? I used to all throughout treatment including chemo but stopped when some conflicting evidence (which I can’t find now) came out. Now I see new evidence linking it to better outcomes. Considering starting it again.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED
2019 NED

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beach sunrise
Posts: 1034
Joined: Thu Mar 05, 2020 7:14 pm

Re: Vit D and immunotherapy

Postby beach sunrise » Wed Sep 16, 2020 6:26 pm

I have been researching high dose vitamin D protocol and like the sound of the benefits. I am going to bring it up for discussion to the ND. I sent him a heads up about it so we will see.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Vana3
Posts: 59
Joined: Tue Aug 13, 2019 11:40 am
Facebook Username: ma

Re: Vit D and immunotherapy

Postby Vana3 » Thu Sep 17, 2020 10:44 am

There was a study at Yale and Dana Farber, it was small group study but it showed Vitamin D is beneficial not sure if that benefit includes stage VI BUT I take it... why not?

https://medicalxpress.com/news/2019-06- ... vival.html
Dx 36 yr, F, 7/19
T4aN2M1 Cea 5
5 cm tumor in cecum removed, 17 + out of 45 LN
Cea 4.2
MSS, KRAS g12d, Braf WT
MT: 10.9
8/20/19 MRI & PET liver spots
9/19 - 3/20 FOLFOX
1/20 CEA 3.6,4.4, 4.6, 4.6
Liver resect 4/15/20
6/20 Ct scan clear
7/20 Cea 8.6
8/20 Cea 12.4, suspicious ovarian cyst
9/20 Hysterectomy SOB CRC
post surgery cea 2.6
11/20 clear scans
2/21 clear scans
4/21 spleen met
5/21 pet scan picks up subtle concerns in liver as well as confirms spleen
Cea 4.6
5/21 to current folfiri
Cea 10

boxhill
Posts: 789
Joined: Fri Apr 06, 2018 11:40 am

Re: Vit D and immunotherapy

Postby boxhill » Mon Sep 21, 2020 10:55 am

I was on immunotherapy and took Vitamin D before and during. I have no idea if it helped.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/20 MRI stable/NED
6/20 Stop Key
All MRIs NED

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henry123
Posts: 218
Joined: Sun Oct 08, 2017 3:25 am

Re: Vit D and immunotherapy

Postby henry123 » Tue Nov 10, 2020 9:43 am

Depending on your skin colour - black , brown or white , daily dose of sunshine is the best solution to ensure your vitamin D levels. Darker your skin colour the longer time you need to be out in direct sunshine. White skinned people need maybe 15to 20 minutes of exposure and up to an hour for really dark skinned people.
Weather permitting , doing shirtless light exercises out in sunshine can be a great overall solution.
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
1/20 NED Opdivo stop
8/23 1.0 All ok


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