Vit D and immunotherapy

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plastikos
Posts: 343
Joined: Wed Jan 14, 2015 6:09 am

Vit D and immunotherapy

Postby plastikos » Tue Sep 15, 2020 11:32 pm

Question for everyone who’s on or has been on immunotherapy, specifically checkpoint inhibitors. Do you take Vit. D supplements or not? I used to all throughout treatment including chemo but stopped when some conflicting evidence (which I can’t find now) came out. Now I see new evidence linking it to better outcomes. Considering starting it again.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED
2019 NED

User avatar
beach sunrise
Posts: 217
Joined: Thu Mar 05, 2020 7:14 pm

Re: Vit D and immunotherapy

Postby beach sunrise » Wed Sep 16, 2020 6:26 pm

I have been researching high dose vitamin D protocol and like the sound of the benefits. I am going to bring it up for discussion to the ND. I sent him a heads up about it so we will see.
8/19 RC CEA 86 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1-21-20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
mFOLFOX6 CEA 7
8 rds 6-10 CEA 11.4 4 more no oxa
6-17 CEA 11.1
7-2 CEA 11.1
7-16 CEA 10.3
7-28 CEA 8.8
8-11 CEA 7.8
9-1 CEA 8.8
9-8 CEA 9
9-16 CEA 9
9-22 CEA 8.6
MHL1+
PMS2+
MSH2+
MSH6+
POLD1
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

Vana3
Posts: 40
Joined: Tue Aug 13, 2019 11:40 am
Facebook Username: ma

Re: Vit D and immunotherapy

Postby Vana3 » Thu Sep 17, 2020 10:44 am

There was a study at Yale and Dana Farber, it was small group study but it showed Vitamin D is beneficial not sure if that benefit includes stage VI BUT I take it... why not?

https://medicalxpress.com/news/2019-06- ... vival.html
Dx 36 yr, F, 7/19
T4aN2M1 Cea 5.1
5 cm tumor in cecum removed, 17 out of 45 LN
1 cm omental deposit removed
LVI +
Cea post surgery 4.2
MSS, KRAS g12d, Braf WT
MT: 10.9
8/20/19 MRI & PET small liver spots
9/19 - 3/20 FOLFOX
1/02/20 CEA 3.6, 2/15- 4.4 3/15- 4.6, 6/05 4.6
Liver resection 4/15/20
6/20 Ct scan clear
7/20 Cea 8.6
8/20 Cea 12.4, suspicious ovarian cyst
9/20 Hysterectomy SOB (Ovaries and uterus positive for CRC)

boxhill
Posts: 589
Joined: Fri Apr 06, 2018 11:40 am

Re: Vit D and immunotherapy

Postby boxhill » Mon Sep 21, 2020 10:55 am

I was on immunotherapy and took Vitamin D before and during. I have no idea if it helped.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 CT NED
11/18 CT NED
12/18 MRI 5mm liver mass, 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
Suspend treatment


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