What next if desensitized chemo(oxi) get allergy?

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Suniva
Posts: 19
Joined: Mon Sep 30, 2019 4:03 pm

What next if desensitized chemo(oxi) get allergy?

Postby Suniva » Wed Sep 09, 2020 6:57 pm

Hi All,
We were doing treatment at mayo Rochester, taking erbitux, folfiri, for 8 cycle first treatment with 4 cycle works as ctscan showed tumors were responding, but Unfortunately after 4 cycle
Of folfiri didn’t respond like at perirectal it increased 2.2 and more small new tumors are seen at both lungs. So doc planned to give folfox and avasti, but he had already got allergic to oxi, he told he can do desensitized chemo by hospitalization. He is able to take first one but Last time my husband got allergic to desensitize chemo (oxi). Doc told folfox is one which have got more success rate but he got allergic and there is no more other good option than that. Do you any one have face these and if you have any suggestion what next treatment can be done on this. Please provide us suggestion on it. Doc also told he is not candidate for immunotherapy or radiation. I am just worrying what next can be done.
Thank u
Suniva
DT 41yrs 10/18 on 3C, and small nod r/l lungs
11 lap surg
12/1805/2019 CAPOX total 8cyc (inc and dec tumor)
09 thoracotomy at right lung took two nodules, still left at left lung.metastatic to lung
10-Started CAPOX again
10/31/19-2nd cycle Allergic to OX taking CAP oral chemo alone for 1 cycle, CT scan showed left nodule inc. from 5to6mm
12/19 ct scan ndoc visit 7mm. Doc want to do 3 cycles of CAP
2/18 pet n ultrasound endo confirmed metastatic to perirectal 4mm
3/16 CT new nods at r/l lungs, inc pelvis

Lee
Posts: 6096
Joined: Sun Apr 16, 2006 4:09 pm

Re: What next if desensitized chemo(oxi) get allergy?

Postby Lee » Thu Sep 10, 2020 5:59 pm

So sorry I was about to suggest immunotherapy until that last sentence.

I know that it is possible to desensitize, it has worked for other people. Butt I may be confused, has he been desensitized in the past?

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

User avatar
ginabeewell
Posts: 452
Joined: Wed Oct 24, 2018 10:30 am

Re: What next if desensitized chemo(oxi) get allergy?

Postby ginabeewell » Thu Sep 10, 2020 10:02 pm

My first time with chemo I did 19 rounds - the first 8 I did FOLFOX and Vectibix (like Erbitux) and then I started to get sensitivity to the Oxy.

So they just took away the Oxy and kept me on the remaining drugs for 11 more rounds. It got me to resectable (although in truth most of that came early on in the process).

Now I am on FOLFIRI + Vectibix but needed a bit of a break and they agreed to hold the Irinotecan for me last round.

So he may not need it in the mix at all?
45 YO mom of twins (9) and lucky stepmom of 14/17 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets CEA 931
10/18 FOLFOX + Vectibix
12/18 typhlitis (7 days in hospital) but largest met down to 5 cm.
12/18 CEA 4.6
1/18 Resume chemo (#6-8)
3/19 HAI pump placement / colon resection
4/19 Resume chemo (#9-19) FOLFOX (no OX) + Vectibix
5/19 CEA 1.3
7/19 liver resection
10/19 liver resection
1/20 NED! CEA 0.6
3/20 two new liver mets; FOLFIRI (5) and then add Vectibix (5)
8/20 CEA 0.7
Resection next?

Suniva
Posts: 19
Joined: Mon Sep 30, 2019 4:03 pm

Re: What next if desensitized chemo(oxi) get allergy?

Postby Suniva » Fri Sep 11, 2020 7:36 pm

ginabeewell wrote:My first time with chemo I did 19 rounds - the first 8 I did FOLFOX and Vectibix (like Erbitux) and then I started to get sensitivity to the Oxy.

So they just took away the Oxy and kept me on the remaining drugs for 11 more rounds. It got me to resectable (although in truth most of that came early on in the process).

Now I am on FOLFIRI + Vectibix but needed a bit of a break and they agreed to hold the Irinotecan for me last round.

So he may not need it in the mix at all?


Actually folfiri+erbitux doesn’t work as tumor are growing so got folfox+avastin but we already got allergic to oxi so did desensitization.
DT 41yrs 10/18 on 3C, and small nod r/l lungs
11 lap surg
12/1805/2019 CAPOX total 8cyc (inc and dec tumor)
09 thoracotomy at right lung took two nodules, still left at left lung.metastatic to lung
10-Started CAPOX again
10/31/19-2nd cycle Allergic to OX taking CAP oral chemo alone for 1 cycle, CT scan showed left nodule inc. from 5to6mm
12/19 ct scan ndoc visit 7mm. Doc want to do 3 cycles of CAP
2/18 pet n ultrasound endo confirmed metastatic to perirectal 4mm
3/16 CT new nods at r/l lungs, inc pelvis

Suniva
Posts: 19
Joined: Mon Sep 30, 2019 4:03 pm

Re: What next if desensitized chemo(oxi) get allergy?

Postby Suniva » Mon Sep 14, 2020 7:00 am

Lee wrote:Butt I may be confused, has he been desensitized in the past?

Lee

Not before but this was second cycle of desensitized which also got allergy.
DT 41yrs 10/18 on 3C, and small nod r/l lungs
11 lap surg
12/1805/2019 CAPOX total 8cyc (inc and dec tumor)
09 thoracotomy at right lung took two nodules, still left at left lung.metastatic to lung
10-Started CAPOX again
10/31/19-2nd cycle Allergic to OX taking CAP oral chemo alone for 1 cycle, CT scan showed left nodule inc. from 5to6mm
12/19 ct scan ndoc visit 7mm. Doc want to do 3 cycles of CAP
2/18 pet n ultrasound endo confirmed metastatic to perirectal 4mm
3/16 CT new nods at r/l lungs, inc pelvis

Lee
Posts: 6096
Joined: Sun Apr 16, 2006 4:09 pm

Re: What next if desensitized chemo(oxi) get allergy?

Postby Lee » Mon Sep 14, 2020 7:09 pm

Was it a bad reaction? Can they keep him on steroids for awhile?

I am just going to throw this out there. I have seasonal allergies which sometime would give me hives. Anything could trigger it, taking a new medicine,etc. Once I got them from shoes, leather flats, that for some reason my body did not like me wearing on an out of town weekend adventure. I had worn those shoes dozens of time before without problems.

Anyway my doctor put me on Allegra over 25 yrs ago (took a presc then), just to see if it might help. I have not had hives since. It not only help, I believe it cured the problem. I still take Allegra today. Maybe something to consider.

Good luck.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

Suniva
Posts: 19
Joined: Mon Sep 30, 2019 4:03 pm

Re: What next if desensitized chemo(oxi) get allergy?

Postby Suniva » Tue Sep 15, 2020 9:51 am

Lee wrote:Was it a bad reaction? Can they keep him on steroids for awhile?
Lee

The redness n itchiness start from hand through all part of body, ya they did steriod and took him rest for hour, and start again with low dose like 2hr took 4 hr and 4 hrs took 6 hrs...
DT 41yrs 10/18 on 3C, and small nod r/l lungs
11 lap surg
12/1805/2019 CAPOX total 8cyc (inc and dec tumor)
09 thoracotomy at right lung took two nodules, still left at left lung.metastatic to lung
10-Started CAPOX again
10/31/19-2nd cycle Allergic to OX taking CAP oral chemo alone for 1 cycle, CT scan showed left nodule inc. from 5to6mm
12/19 ct scan ndoc visit 7mm. Doc want to do 3 cycles of CAP
2/18 pet n ultrasound endo confirmed metastatic to perirectal 4mm
3/16 CT new nods at r/l lungs, inc pelvis


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