I am currently doing FOLFIRI, I did FOLFOX at the beginning of my journey about 12 rounds. My neuropathy has cleared up in my hands, but I get it in my feet and shin still, usually during bedtime. I feel numb or tingly. My Doctor's plan is to do FOLFIRI for 4-6 rounds (I have my 4th round tomorrow) to beat up the cancer as much as possible and lower my CEA as low as possible. This is not maintenance chemo, this is hard core kick your ass chemo. Just like FOLFOX, FOLFIRI is tough, albeit both have different side effects. I have more nausea, hair loss with FOLFIRI, FOLFOX I had cold sensitivity, first bite syndrome (jaw pain on first bite) and neuropathy, never nauseous or lost hair, maybe thinning of hair.
Maintenance chemo is basically simpler and less to no side effects. Xeloda is not harder at all, I did it and the only side effect I had was my hands and feet got darker, Hyper Pigmentation its called. I am brown so I don't know how it affects someone that is White. Along with Xeloda you would get Avastin at the infusion center, which is 30 minutes and your done. Avastin has really no side affect other then maybe feeling a little dizzy after infusion but goes away quickly.
I hope this helps. Glad your husband is well and everything is good so far. FOLFOX does suck so does FOLFIRI.
All the Best,
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.