I am kind of a newbie, so please correct me if I say something incorrect.
I understand Colon Cancer is typically graded based on TNM criteria and this grade is mapped into a more simplistic "Stage"
As part of TNM they take into account the tumor growth, the invasion of nearby areas, organs, lymph nodes and distant metastases.
I was personally pretty happy when my doctor told me my TNM was T3N0M0, in fact I almost cried from joy during the appointment when I learnt I had no limphatic Nodes involvement, no limphatic invasion and no spread to the spleen. Doctor said, that my case would be looked into in the committee session, but it was not certain that chemo would be recommended.
But then, upon reading my report I see "perineural invasion present".... I googled it and it appears it is a predictor of poor prognosis, not different from limphatic invasion, in fact according to a few studies, it is a risk factor and enough to recommend chemo in Stage II patients.
Do you guys know much about this perineural invasion? I see many people don´t have any mentiont to it in their signature, also most studies about it are fairly recent.
Is it that bad? Have people here managed to remain NED (or cured) even with PNI present?
Thanks to all, BR
Last edited by I_will_fight
on Thu Jul 23, 2020 12:49 pm, edited 1 time in total.
46 yo male at DX from Spain
June 2020 - 6 cm T3N0M0 cancer on left colon
No evidence of liver mets, two milimetric dots in lung, 3 and 4 mm (currently not considered mets)
lymph nodes 0/37
MSH6 non expressed, other MMR proteins present
KRAS mt G13D
Vascular invasion: absent
July 8th 2020 - 50 cm colon and spleen removed, clean margins, optimistic surgeon.
Aug 2020 - start of XELOX regime, four cycles.