Stage III's

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beach sunrise
Posts: 287
Joined: Thu Mar 05, 2020 7:14 pm

Stage III's

Postby beach sunrise » Fri Jun 05, 2020 12:50 pm

Hi, going in Monday for round 8 folfox6. Had discussion with onc about doing 4 more rounds of at least 5FU. He said no evidence was found for that protocol any more, 8 is it and I should just relax and see if/when cancer shows up again. Nothing to do but have patience and wait. Scan was clean last Monday but CEA was 11.4, down from 12. My thought is cancer is still just circling looking for place to set up camp to build a community then 4 more rounds gives a better chance of killing the micromets before they set up to make me stage IV (might be already, who knows). I do have a second opinion in the works but might not be soon enough, Idk. Anyone here still doing 12 rounds?
8/19 RC CEA 86 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
MHL1+
PMS2+
MSH2+
MSH6+
POLD1
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

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ANDRETEXAS
Posts: 652
Joined: Fri Feb 14, 2014 11:01 am
Location: Austin, Texas (University of Tennessee alumnus)

Re: Stage III's

Postby ANDRETEXAS » Fri Jun 05, 2020 1:49 pm

I know there are people who do not take 12 rounds for a variety of reasons, but when did the protocol change? I finished my FOLFOX in August, 2014. My Oncologist and I both wanted to go 12, but the doctor did ask me if I wanted to cut back on the oxi. I told him No since I was handling it fairly well. Andre
2014
2/10 - Colon resect
2/13 - DX- Stage IIIb
6 of 18 lymph nodes cancerous
3/7 - Port placed
3/11 - FOLFOX (12 rds w/full oxi)
8/14 - Chemo finish
8/25 - CT- Inc
9/5 - clean PET
12/10- clean CT
2015
3/2 - Clean colonoscopy & port removed
3/4- clean CT
9/21- clean CT
2016
3/23- clean CT
2017
2/22- clean CT
2018
3/21 - clean CT
4/11 - clean colonoscopy
2019
3/11 - clean CT
9/23 - Five-year release - Annual visits now !
Next colonoscopy - 2023

ONE DAY AT A TIME !

User avatar
beach sunrise
Posts: 287
Joined: Thu Mar 05, 2020 7:14 pm

Re: Stage III's

Postby beach sunrise » Fri Jun 05, 2020 2:03 pm

He said we are being aggressive with 8 considering newest scientific evidence said 6 rounds is just as good as 12. Idk when protocol changed but that was his answer.
8/19 RC CEA 86 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
MHL1+
PMS2+
MSH2+
MSH6+
POLD1
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

Claudine
Posts: 440
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Stage III's

Postby Claudine » Fri Jun 05, 2020 2:23 pm

When DH was on Xelox, he had 6 cycles, but I found a scientific publication that described the last 2 as not having additional benefits and as more likely to result in permanent neuropathy. Which unfortunately is what happened.
It was not this one, but that gets to the same point:
https://www.futuremedicine.com/doi/full ... -2017-0019
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 24.1
Scan 03/19: Multiple small lung nodules, now gone
PET 04/20 uptake by L4
L3-L4-L5 fusion surgery and partial corpectomy 05/20
Scan 09/20: nothing to report

margiej
Posts: 104
Joined: Sat Apr 14, 2018 8:46 am

Re: Stage III's

Postby margiej » Fri Jun 05, 2020 2:31 pm

I also did six rounds of capeox in 2016. My oncologist thought 8 was likely too much, 4 possibly too little, and that six was hopefully the sweet spot. I do have some permanent neuropathy in my feet and fingertips....maybe 5 rounds would have been perfect?
Margie
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/2017 and 1/2020
CT 10/3/17 clear
CT 10/17/18 clear
CT 10/17/19 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

polluxx
Posts: 50
Joined: Thu Jul 10, 2008 9:41 pm

Re: Stage III's

Postby polluxx » Fri Jun 05, 2020 2:37 pm

Monday, I have FolFox treatment 6 of 12. I’ve also read studies that show that 6 treatments are as effective as 12, however, my oncologist is adamant that I need all 12, so 12 it is. We have had to reduce the Oxiplaplatin by 15% and I’m resigned to the idea that it may need to be reduced farther before I complete treatment.
Stage 3c
2/2020 Right colon hemicolectomy (invasive adenocarcinoma with micropillary features)
Moderately differentiated
Tumor size: 4.4 in greatest dimension Metastatic Carcinoma in 12 out of 28 lymph nodes
Extranodal extension identified
Margins negative

3/2020 Began 12 rounds of FolFox

User avatar
beach sunrise
Posts: 287
Joined: Thu Mar 05, 2020 7:14 pm

Re: Stage III's

Postby beach sunrise » Fri Jun 05, 2020 10:28 pm

Thanks all of you for your input!!! I really appreciate it. I need ammo to back me up. I have tolerated folfox very well and can do 4 more in hopes cea goes way down. Its good to know you are doing 12 rounds, pollux! Only side effect is cold sensitivity, no big deal at all especially compared to cancer starting a community. I don't even complain about the cold sensitivity at appts because its random in 90 degree plus heat here.
8/19 RC CEA 86 T3N0M0
Neoadj 5FU/rad 6 wk
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
8 rds 6-10 CEA 11.4 4 more no oxa
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
MHL1+
PMS2+
MSH2+
MSH6+
POLD1
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"


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