when CEA is not a good indicator.

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polluxx
Posts: 36
Joined: Thu Jul 10, 2008 9:41 pm

when CEA is not a good indicator.

Postby polluxx » Thu May 21, 2020 3:24 pm

My presurgery CEA was 1.2. My oncologist said that she did not think CEA would be a good indicator for me because I had a pretty hefty cancer load at that time.

She is, however, continuing to monitor my levels.

February 23=1.2
March 25=0.6
April 27=.9
May 20=1.5

Tuesday, I go in for my 5th FolFox cycle. I can’t help but wonder if the rise in CEA means that the chemo is not being effective.

My surgeon believes that he got all of the present cancer during my surgery, so there shouldn’t be anything we can monitor with a scan.

I see my oncologist again in a month. I’m wondering if I should send her a message about this or just wait until I see her again.

I’m off to do more research.
Stage 3c
2/2020 Right colon hemicolectomy (invasive adenocarcinoma with micropillary features)
Moderately differentiated
Tumor size: 4.4 in greatest dimension Metastatic Carcinoma in 12 out of 28 lymph nodes
Extranodal extension identified
Margins negative

3/2020 Began 12 rounds of FolFox

User avatar
CRguy
Posts: 10144
Joined: Sun Feb 10, 2008 6:00 pm

Re: when CEA is not a good indicator.

Postby CRguy » Thu May 21, 2020 11:54 pm

I don't want to throw too much at you ... BUTT .... :shock:
CEA was never a marker for me and we eventually added CA 19-9 + LDH ... also always been OK

MORE imaging + More specialists looking at your situation = better IMO

" Don't take radiation/oncology advice from a surgeon .... etc. etc. etc. ..."

SO talk with your Onc. Sometimes CEA "trends" can be important ... BUTT
CEA is known to increase with successful treatment which nukes the tumor etc.

AND CEA can increase with most any inflammation in the body, so your minor increase could well be nothing at all related to cancer

JMO

BTDT !

Cheers and best wishes for getting more info
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
13 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Rock_Robster
Posts: 495
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: when CEA is not a good indicator.

Postby Rock_Robster » Fri May 22, 2020 9:25 am

polluxx wrote:My presurgery CEA was 1.2. My oncologist said that she did not think CEA would be a good indicator for me because I had a pretty hefty cancer load at that time.

She is, however, continuing to monitor my levels.

February 23=1.2
March 25=0.6
April 27=.9
May 20=1.5

Tuesday, I go in for my 5th FolFox cycle. I can’t help but wonder if the rise in CEA means that the chemo is not being effective.

My surgeon believes that he got all of the present cancer during my surgery, so there shouldn’t be anything we can monitor with a scan.

I see my oncologist again in a month. I’m wondering if I should send her a message about this or just wait until I see her again.

I’m off to do more research.

I’m not sure if it helps, but the lab I use doesn’t usually even report CEAs below 2 (ie they just give “<2”) as they don’t think it is clinically meaningful at these levels.

Good luck,
Rob
Male 38; Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9.
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic VMAT radiation; complete metabolic response
07/19 ULAR (robot), temp ileo, 1/27 LN
08/19 Missed a liver spot
08-11/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection #2
02/20 Ileostomy reversed
03/20 PET & MRI = NED!

Claudine
Posts: 346
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: when CEA is not a good indicator.

Postby Claudine » Fri May 22, 2020 10:18 am

DH's onc told us that he's not worried until CEA gets into the double digits...
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 7.6
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: one 1mm stable nodule
PET 04/20 small uptake by L4
L3-L4-L5 fusion surgery and residual tumor removal 05/20

boxhill
Posts: 520
Joined: Fri Apr 06, 2018 11:40 am

Re: when CEA is not a good indicator.

Postby boxhill » Fri May 22, 2020 10:51 am

My CEA was almost 4 at diagnosis/surgery, and was declared to be not a marker for me. Since then it has moved up to 6 and 8, and currently is 5.3. No one really pays any attention to it.

It is not a marker for about 30% of us. I regard it as one less thing to obsess about! :D
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 CT NED
11/18 CT NED
12/18 MRI 5mm liver mass, 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
Suspend treatment


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