Reducing Oxaliplatin

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polluxx
Posts: 36
Joined: Thu Jul 10, 2008 9:41 pm

Reducing Oxaliplatin

Postby polluxx » Sat May 16, 2020 1:38 pm

I just finished my fourth out of twelve cycle of FolFox. I’ve had more nausea than my oncologist expected, and I had sensitivities to some of the anti nausea meds that caused migraines, but it seems like we have tweaked those and Emend seems to keep it pretty well under control.

I’ve had burning/tingling in my hands since my second cycle, but this cycle, there is numbness in my hands and feet and lips even when I’m not touching anything cold.

At my appointment, yesterday, I asked my oncologist if I didn’t need to worry about neuropathy so long as it subsides between treatments. She said that she isn’t comfortable waiting longer to reduce my Oxaliplatin by 15% because I’m too young to have trouble even walking when I’m finished with treatment.

I feel conflicted. Of course, my goal was to get through all 12 cycles at a full dosage. At least,I thought I’d be able to do that for seven or eight cycles. After the fourth seems so early.

On the other hand, I’m looking forward to the possibility of less harsh side effects.

I’m already taking 600 mg of Gabapentin I also have Glutamine, but I haven’t been taking it.

Is there anything you can think of that might help me get through the eight cycles without having to reduce the Oxaliplatin even more?
Stage 3c
2/2020 Right colon hemicolectomy (invasive adenocarcinoma with micropillary features)
Moderately differentiated
Tumor size: 4.4 in greatest dimension Metastatic Carcinoma in 12 out of 28 lymph nodes
Extranodal extension identified
Margins negative

3/2020 Began 12 rounds of FolFox

JJH
Posts: 290
Joined: Mon Apr 24, 2017 7:26 am

Re: Reducing Oxaliplatin

Postby JJH » Sat May 16, 2020 1:56 pm

polluxx wrote:...Is there anything you can think of that might help me get through the eight cycles without having to reduce the Oxaliplatin even more?

You might ask your oncologist about IV Vitamin B12. My oncologist gave me an injection of Vitamin B12 once for peripheral neuropathy, but that was all. I don't know if it is a viable long-term solution. I only managed to finish 4 cycles of Xelox before I had to quit.

High-Dose Vitamin B12 as a treatment for Peripheral Neuropathy
https://www.naturopathiccurrents.com/news/high-dose-vitamin-b12-treatment-peripheral-neuropathy
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

polluxx
Posts: 36
Joined: Thu Jul 10, 2008 9:41 pm

Re: Reducing Oxaliplatin

Postby polluxx » Sat May 16, 2020 2:11 pm

Awesome! Thank you. I’m going to bring that up with her.
Stage 3c
2/2020 Right colon hemicolectomy (invasive adenocarcinoma with micropillary features)
Moderately differentiated
Tumor size: 4.4 in greatest dimension Metastatic Carcinoma in 12 out of 28 lymph nodes
Extranodal extension identified
Margins negative

3/2020 Began 12 rounds of FolFox

Koreysue
Posts: 147
Joined: Mon Apr 30, 2018 2:36 pm

Re: Reducing Oxaliplatin

Postby Koreysue » Tue May 19, 2020 10:26 pm

Hello, I made it to 6 cycles full dose, then reduced for 4 more, then dropped completely at 10.
I really think that L- glutamine helped me. I would take it the day before each cycle, and each day during, along with the day after.
I dissolved it in water.
Hope that helps,
Koreysue
Diagnosed: June 2017 stage 3 colon cancer
Sigmoid colon, 2 nodes affected
CEA at diagnosis: 6
Sigmoid Colectomy and folfox (chemo complete January 31, 2018)
CEA 4/2018: 2.4
CEA 7/2018: 3.7
Colonoscopy 8/2018 clean
PET scan 8/20/18 clear (cea rise a mystery for now, doc said maybe all the smoke in my town from forest fires)
CEA 11/2018: 3.8
CEA 2/2019: 3.2
CT clear 6/18/2019 / CEA : 3.4
CEA 10/21/19: 3.2
CEA 3/9/20: 3.8 :| My dr. wasn’t concerned, but I asked for a retest in 1 month


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