Aspirin question

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margiej
Posts: 93
Joined: Sat Apr 14, 2018 8:46 am

Aspirin question

Postby margiej » Sat May 09, 2020 8:32 am

Hi...I was reading this recent study about aspirin and rates of colon cancer. My doctor has me taking 81 mg per day...the usual low-dose aspirin. This study suggests that a higher dose might provide more benefit. I will ask about this at my next appointment, but I was curious what your doctors recommend for you right now. Thank you!
Margie

https://www.ascopost.com/news/april-202 ... ive-tract/
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/2017 and 1/2020
CT 10/3/17 clear
CT 10/17/18 clear
CT 10/17/19 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

Cured
Posts: 552
Joined: Thu Nov 27, 2008 10:53 pm
Location: MO

Re: Aspirin question

Postby Cured » Sat May 09, 2020 10:45 am

Dear Margie, It’s been believed for a long time that aspirin is prophylactic for colon cancer. Full regular 325mg aspirin; inexpensive. Get coated ones to help protect the stomach.
(I haven’t read the study you attached.)

Along with this I take psyllium fiber everyday & my colon has been clear ever since the cancer was surgically removed. I use Konsyl- which is like Metamucil without the sugar. I use 1/2-1 teaspoon in water twice a day.
5-08:Stg 3 Rectal: 6/14 Nodes
Ace Surgn Remvd 90%Rectm,lots of Colon-Full Incision
Ileo Rev'd 6 Mos.
Radiatn+5fu Pre-Surgery
FOLFOX 8 CyclDone 1-09
Clear Scope 8-17; CEA 2-18
Glory to God! Healed by prayers of many: for 10 yrs
7-18: tumor pressing against brain Removed
Metastatic to lung. CEA 6.9
Folfiri
CEA to 4.5 after 1 chemo
After 8rds CEA 3
CEA 1.8, 2.3,1.7,2.2,5.7
12 rds Folfiri
Avastin evy 3 wks
Seizure Anti-seiz meds work-no driving for 6 mo
Neuro allows to drive again
PET: Lung spots Chemo

User avatar
CRguy
Posts: 10138
Joined: Sun Feb 10, 2008 6:00 pm

Re: Aspirin question

Postby CRguy » Sat May 09, 2020 4:49 pm

Here is the actual paper which the ASCO text is abstracted from https://www.annalsofoncology.org/article/S0923-7534(20)36073-7/fulltext
and ASCO has added this disclaimer
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.

This work was funded by a grant from Bayer = aspirin !!!
and seems to be more of a comment on an interesting bit of info as opposed to a definitive medical recommendation
as it is " a systematic review and meta-analysis of all observational studies on aspirin and cancers of the digestive tract "

FYI I do take the low dose ( 81mg daily aspirin ) and have done since before my CRC diagnosis , SO ...
I can clearly say that dose did not prevent my CRC. There are still benefits for using ASA and IF it may help some reduce their risk factors
I say GREAT !!!!

Would like to see more / better anaylses of this topic as ASA is cheap medication which could be of great benefit.

JMO

Cheers all
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
13 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

boxhill
Posts: 516
Joined: Fri Apr 06, 2018 11:40 am

Re: Aspirin question

Postby boxhill » Sun May 10, 2020 11:14 am

Taking daily aspirin is always a balancing act between benefits and potential bleeds in the brain or elsewhere. IMHO, you and your doctors would need to take a hard look at your whole medical picture and other meds before deciding to take anything more than a baby aspirin daily.

Personally, I do take a daily baby aspirin, but not in the hopes of preventing further colon cancer.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
Neulasta 6/28
7/18 CT NED
11/18 CT NED
12/18 MRI 5mm liver mass, 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: many fails before Celebrex helps
12/23/19 CT stable

Gravelyguy
Posts: 299
Joined: Thu Jul 05, 2018 6:03 pm

Re: Aspirin question

Postby Gravelyguy » Mon May 11, 2020 9:09 am

Timely thread!

I have been taking a low dose aspirin for a couple years now as I read similar reports. I have an upcoming June appointment with my Onc at Mayo. It is my understanding that he has published some studies about the use of aspirin to prevent recurrence of CRC. I have met with his NP the last three times, love her, but this is on my list of questions to ask him.

I don't mind taking it but not sure of dosage and the blood thinner part of the equation is bothersome. Any kind of cut seems to bleed for ever!

I will report back what he says.

Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0
12/19/19 clear scans CEA 1.0 still NED!

margiej
Posts: 93
Joined: Sat Apr 14, 2018 8:46 am

Re: Aspirin question

Postby margiej » Mon May 11, 2020 12:22 pm

Gravelyguy wrote:Timely thread!

I have been taking a low dose aspirin for a couple years now as I read similar reports. I have an upcoming June appointment with my Onc at Mayo. It is my understanding that he has published some studies about the use of aspirin to prevent recurrence of CRC. I have met with his NP the last three times, love her, but this is on my list of questions to ask him.

I don't mind taking it but not sure of dosage and the blood thinner part of the equation is bothersome. Any kind of cut seems to bleed for ever!

I will report back what he says.

Dave


Thanks, Dave..will be interesting to hear his thoughts. You must be in my neck of the woods...I am in Western Wisconsin.
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/2017 and 1/2020
CT 10/3/17 clear
CT 10/17/18 clear
CT 10/17/19 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

Gravelyguy
Posts: 299
Joined: Thu Jul 05, 2018 6:03 pm

Re: Aspirin question

Postby Gravelyguy » Mon May 11, 2020 1:35 pm

margiej wrote:
Thanks, Dave..will be interesting to hear his thoughts. You must be in my neck of the woods...I am in Western Wisconsin.



Hi Margie,

I am in Central MN, so pretty close. I was at Mayo for surgery and radiation and now all of my follow ups.

Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 clear scans, CEA .9 still NED!
6/11/19 clear scans CEA 1.0
12/19/19 clear scans CEA 1.0 still NED!


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