Hopepray wrote:... I am worried after reading many posts here on Xeloda dosing as most seem to have a 3000mg per day. I know it's weight dependant and she's around 68kgs or 150lbs...

Hopepray wrote:...My mom is 150lbs and 5.3 ft as I noted in my previous reply which I am not sure has been approved yet.

Hopepray wrote:...She is around 150lbs and 5 feet 3 inches.

Thank you for the update. I will assume that your mom is 5 feet 3 inches and not 5.3 feet. (5.3 feet is more like 5 feet 4 inches.)

With this information we can calculate the correct dose for your mom.

First, let me say that the standard Xeloda dose for use with neo-adjuvant radiation is usually

825 mg/m2. (This is different from the standard dose used in Capeox (Xeloda + oxaliplatin), and it is different from the standard dose that sdino's wife had under her regimen of Xeloda +Avastin. In these matters you have to pay very close attention to the particular regimen that Xeloda is being used in.) Your mom was on the regimen "Neoadjuvant Capecitabine / Radiation Therapy"

Here is a table showing the standard

There is one thing in this table that is very, very important. It is the acronym

bid, which in Latin means "twice a day". So, this standard dose of

825 mg/m2 needs to be taken twice a day (i.e., morning and evening)

With your mom's height and weight we can use a BSA calculator to get her Body Surface Area. Then in the second part of the calculator we can calculate how many milligrams of Xeloda your mom should have taken in the morning and how many in the evening.

By using a height of 63 inches and a weight of 150 pounds, the calculator will show her Body Surface Area. (Note: In the on-line form you have to first click on the down-arrows to change the height units from centimeters to inches, and the weight units from kilograms to pounds before you click on "Calculate Body Surface Area". Also, you have to enter 825 in the Drug dosage/M2 box so that the calculator wil do the conversion.)

Once you have done all this and clicked on the "Calculate" button you will see the Results:

BSA = 1.71

Dose = 1410.75 bid

In other words, the correct morning dose is 1410.75 and the correct evening dose is 1410.75, for a total daily dose of 2821.50 mg.

To approximate 1410.75 with the available pill sizes of 500 mg and 150 mg, the pharmacist might prescribe 2 large pills and 3 small pills every morning and every evening. Or he might decide to do the approximation in a different way.There is no way to come up with exactly 1410.75mg with only 500 mg and 150 mg pills.

BSACalculatorhttps://globalrph.com/medcalcs/body-surface-area-bsa/So, if these calculations are correct, then your mom received only about half of the Xeloda that she should have received. If this is true, I don't know why. Maybe the doctor or pharmacist wrote the prescription as "1,500 mg. bid" but didn't explain what bid meant.

You need to have a professional look into this soon, before they start the CAPEOX cycles, because if they did the calculations wrong for the 5 weeks of chemo/radiation they might make the same kind of mistake in the CAPEOX dosing.

Let us know what you find out.

Thank you.