FOLFOX differences

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beach sunrise
Posts: 26
Joined: Thu Mar 05, 2020 7:14 pm

FOLFOX differences

Postby beach sunrise » Sun Mar 22, 2020 4:21 am

Why is there a FOLFOX6 and FOLFOX7? When and why is one used over the other? I am really curious about this. I am on FOLFOX6 for my stage IIIC.
Dx 8/19, RC, CEA 86, clinical T3N0M0
Neoadj 5FU/rad 6 wks
Surgery Jan 2020, neg margins T4bN1a IIIC G2 MSI- 1/20 LN+
presurg cea 24/post 5.9
Adj FOLFOX6, cea 7
1st rd complete, 2nd 3/9/20
MHL1 +
PMS2+
MSH2+
MSH6+
Post surg chemo sensitivity testing at Nagourney Cancer Institute "Test failed due to neo-adj chemorad did its job. Not enough cancer cells to test." Good news cancer pretty much dead, bad news not knowing what chemo would work best for my cancer

User avatar
GrouseMan
Posts: 832
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: FOLFOX differences

Postby GrouseMan » Wed Mar 25, 2020 10:12 am

Mostly they differ in the timing and dosage of the components that make up the drug combination. Oncologists select the protocol based on their experiences more than anything else I think. Personal preference maybe. By and large I don't think there is much difference clinically in the outcomes depending on which protocol is used. Lot of experimentation with this drug combination in Oncology practice. Seems its more likely they add bevacizumab now a days to one of these FOLFOX protocols which does seem to make a difference to many.

Have a look at the following about FOLFOX:
https://www.sciencedirect.com/topics/me ... try/folfox

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

beach sunrise
Posts: 26
Joined: Thu Mar 05, 2020 7:14 pm

Re: FOLFOX differences

Postby beach sunrise » Wed Mar 25, 2020 3:59 pm

Thank you so much, Grouseman!
Dx 8/19, RC, CEA 86, clinical T3N0M0
Neoadj 5FU/rad 6 wks
Surgery Jan 2020, neg margins T4bN1a IIIC G2 MSI- 1/20 LN+
presurg cea 24/post 5.9
Adj FOLFOX6, cea 7
1st rd complete, 2nd 3/9/20
MHL1 +
PMS2+
MSH2+
MSH6+
Post surg chemo sensitivity testing at Nagourney Cancer Institute "Test failed due to neo-adj chemorad did its job. Not enough cancer cells to test." Good news cancer pretty much dead, bad news not knowing what chemo would work best for my cancer


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