COVID19 and Immunotherapy

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plastikos
Posts: 338
Joined: Wed Jan 14, 2015 6:09 am

COVID19 and Immunotherapy

Postby plastikos » Sun Mar 15, 2020 8:24 am

Hi again. Have not checked in for a while. Happy to report that I am ok. Just some scans coming up. Little over 5 years from my Stage IV diagnosis and coming up on 3 years NED.

Not sure if this has been discussed. But do you think being on or having been on any form of immunotherapy (i.e. checkpoint inhibitors) has any implication on getting infected by the coronavirus and getting COVID19? We’re read that people with compromised immune systems have it tougher. I know as cancer patients we traditionally fall under that category. But does a ramped up immune system give you a theoretical advantage? This is all in theory.
Last edited by plastikos on Sun Mar 15, 2020 7:01 pm, edited 1 time in total.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED
2019 NED

stu
Posts: 1300
Joined: Sat Aug 17, 2013 5:46 pm

Re: COVID19 and Immunotherapy

Postby stu » Sun Mar 15, 2020 1:30 pm

Hi ,
So great to hear you are doing so well .
That crossed my mind too .
My friend had to go onto steroids as she had a drop in her kidney function . She had a few brain mets pop up a couple of months later . They are under control but they are doubling her immunotherapy every two weeks to get it going .
She is social distancing just now but it’s difficult to achieve with three kids .
Hope your right ,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

boxhill
Posts: 491
Joined: Fri Apr 06, 2018 11:40 am

Re: COVID19 and Immunotherapy

Postby boxhill » Sun Mar 15, 2020 8:38 pm

Excellent question, plastikos. I haven't been able to find anything one way or another, except speculation that the unrestrained immune system might go nuts when challenged by the virus and over-react.

But again...totally speculation.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
Neulasta 6/28
7/18 CT NED
11/18 CT NED
12/18 MRI 5mm liver mass, 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: many fails before Celebrex helps
12/23/19 CT stable


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