Unconventional T cells capable of killing different types of cancer while sparing healthy cells

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boswind
Posts: 74
Joined: Fri Apr 11, 2014 12:04 pm

Unconventional T cells capable of killing different types of cancer while sparing healthy cells

Postby boswind » Wed Feb 26, 2020 3:05 pm

Any comments about this article recently published in Nature: Immunology:
"Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1"?
https://www.ncbi.nlm.nih.gov/pubmed/31959982/
https://acir.org/weekly-digests/2020/fe ... ng-t-cells
https://www.cardiff.ac.uk/people/view/7 ... ell-andrew
01.24.14 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.14 Completed 5-week Radia+Xeloda
05.07.14 Had surgery
02.25.15 CT showed stage 4 inoperable
03.15 - 08.15, folfox + Avastin
08.15 - 07.17, 5FU+leucovorin+Avastin
07.17 - 01.18, Folfuri + Avastin
02.18 - 03.19, Centuximab + Irinotecan
03.19 - 05.19, Keytruda
05.19 - 9.19, Folfox+Avastin
10.19 -01.20: Centuximab+Irinotecan
03.20 - 06.20: STIVARGA
07.20 - present: lonsurf+Avanstin
MSS, KRAS wt, BRAF wt
131 rounds of chemos received (as of 12.31.20)

User avatar
CRguy
Posts: 10474
Joined: Sun Feb 10, 2008 6:00 pm

Re: Unconventional T cells capable of killing different types of cancer while sparing healthy cells

Postby CRguy » Mon Mar 02, 2020 12:13 am

While I have not had a chance to chew over or digest ALL the implications of these announcements
(( hoping GrouseMan will chime in !!! )) Thank you for posting

these are HUGE discoveries for immuno research on a global level, with "generic" responses to many specific cancers !

We are also seeing similar "generic" response research in the SARS/MERS/Ebola/Zika/Covid-19 arena.
A local research team has identified a substance which blocks viral attachment at the infection stage,
rendering it a possible post infection medication which prevents the disease from developing ....
and seems to be useful for many viral infections !
A clinical trial is just starting in Wuhan China, epicenter of the COVID-19 outbreak

Cheers
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

Koreysue
Posts: 258
Joined: Mon Apr 30, 2018 2:36 pm

Re: Unconventional T cells capable of killing different types of cancer while sparing healthy cells

Postby Koreysue » Sun Mar 08, 2020 11:19 pm

Sounds promising :)
Dx: 6/2017 stage 3 CC
Sigmoid, 2 nodes
CEA at dx: 6.1
Sigmoid Colectomy/folfox (last chemo (1/31/18)
CEA 4/2018: 2.4
CEA 7/2018: 3.7
Colonoscopy 8/18 clean
PET scan 8/20/18 NED
CEA 11/2018: 3.8
CEA 2/2019: 3.2
CT NED 6/18/19 / CEA : 3.4
CEA 10/21/19: 3.2
CEA 3/9/20: 3.8
CT NED /CEA 6/17/20: 3.8
CEA 11/4/20 4.6 <——— whyyyy? (will retest in a few weeks)
CT NED 12/1/20 CEA: 3.5
CEA 5/21 4.2
CEA 10/21 3.4
colonoscopy 10/21 10mm polyp
CEA 4/22 3.7
CEA 7/22 3.8
CEA 12/22 4
CEA 1/22 3.2 and NED 5yr scan


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