Anyone heard about TAS102?

Please feel free to read, share your thoughts, your stories and connect with others!
Mercy110
Posts: 114
Joined: Wed Aug 16, 2017 12:13 am

Anyone heard about TAS102?

Postby Mercy110 » Wed Feb 12, 2020 12:15 am

After receiving the treatments (please take a look at my signature), pet scan showed my mum’s rectum might have another tumour again. She had thus received radiotherapy for 25 times in December and now taking rest.

The doctor now suggested my mum to start TAS102 now but we had never heard about this drug in HK. Can anyone give us some comment on the drug and side effect? Her CEA was about 217.3 now, but she could still manage self care.
My Mum (age 56), NRAS-mutate Q61R
2017-05: Surgery with stoma. T4N1M0. Stage3C. Xeloda Only. Increasing CEA. CT: Multiple lung nodules. Stage4.
2017-09: 85% FOLFOX + Avastin, stable CT
2018-03 to 05: Folfox Allergy, Folfiri (with Avastin since Oct)
2019: CEA:178, started Irinotecan+Zaltrip+TS-1, 25 times radio with xeloda
2020: CEA: 217.3, pending treatment


WISH ALL MIGHTY GOD HEALS MUM WITH HIS MIRACLE

Rock_Robster
Posts: 517
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Anyone heard about TAS102?

Postby Rock_Robster » Wed Feb 12, 2020 5:33 am

Hi Mercy110,

TAS102 is more commonly known as Lonsurf, which may help with your research. I don’t have first hand experience with this but others here might.

Best of luck,
Rob
38M Australia
10/2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1
11/18 FOLFOX x6
3/19 Liver resect
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resect
02/20 Ileo reversed
03/20 NED (PET+MRI)
06/20 NED (CT+MRI)
07/20 Clear scope
09/20 NED (PET)

User avatar
GrouseMan
Posts: 837
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Anyone heard about TAS102?

Postby GrouseMan » Wed Feb 12, 2020 10:15 am

Perhaps this link to Wikipedia will be useful. As I recall reading it seems to be more commonly used in Japan for some reason.

https://en.wikipedia.org/wiki/Trifluridine/tipiracil

Its a similar to Xeloda or 5-FU treatment, though is newer. I think if you search for it using the search function on these forums you may find posts about it in the past here.

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

Mercy110
Posts: 114
Joined: Wed Aug 16, 2017 12:13 am

Re: Anyone heard about TAS102?

Postby Mercy110 » Thu Feb 13, 2020 2:28 am

Thank you so much for the replies. I do found some more information with the name Lonsurf. Anyone with first-hand experience here for the drug? My mum had tried Xeloda / 5-fu before but this drug alone seems not so promising... makes me wonder how useful Lonsurf could be.
My Mum (age 56), NRAS-mutate Q61R
2017-05: Surgery with stoma. T4N1M0. Stage3C. Xeloda Only. Increasing CEA. CT: Multiple lung nodules. Stage4.
2017-09: 85% FOLFOX + Avastin, stable CT
2018-03 to 05: Folfox Allergy, Folfiri (with Avastin since Oct)
2019: CEA:178, started Irinotecan+Zaltrip+TS-1, 25 times radio with xeloda
2020: CEA: 217.3, pending treatment


WISH ALL MIGHTY GOD HEALS MUM WITH HIS MIRACLE

Rock_Robster
Posts: 517
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Anyone heard about TAS102?

Postby Rock_Robster » Thu Feb 13, 2020 4:08 am

Mercy110 wrote:Thank you so much for the replies. I do found some more information with the name Lonsurf. Anyone with first-hand experience here for the drug? My mum had tried Xeloda / 5-fu before but this drug alone seems not so promising... makes me wonder how useful Lonsurf could be.

Again no first hand experience, but my understanding is this: it seems that the *average* benefit that people get from this drug is fairly modest, at best. However a proportion of people will do better than the average (and in some cases, a lot better) and it is difficult to know beforehand which they will be. So I can see an argument for trying the drug to see if the response is on the better side of the median. The side effects can also be somewhat rough, so they’ll likely watch blood counts etc closely as well.
38M Australia
10/2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1
11/18 FOLFOX x6
3/19 Liver resect
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resect
02/20 Ileo reversed
03/20 NED (PET+MRI)
06/20 NED (CT+MRI)
07/20 Clear scope
09/20 NED (PET)

jep
Posts: 256
Joined: Sun Jun 11, 2017 7:45 pm
Location: New England, USA

Re: Anyone heard about TAS102?

Postby jep » Sat Apr 11, 2020 6:07 pm

Hi Mercy110 . . . any updates on the Lonsurf? Just looking for some input, as my husband will start Lonsurf within the next 2 weeks . . . let me know how it's been going . . . hope all is well for you and your mum <3
Stage IV CC 5/16/17
Loc: recto-sig
Type: Adenocarcinoma
Size: 7.4 cm
Grade: G3
TNM: T3N2M1
LNs: 8/20
BL CEA: .9
LVI: present
Perineural invasion: present
LAR margins: clear (w/in microns)
Folfox (8/17-1/18)
Scope 6/18 - CLEAR! - 2 polyps
PET 10/17/18: 3 pos LNs
Irino + Vecti (11/18)
CEA: 1.7 (2/19)
Xel + rad (5/19)
Surgery: 8/21/19 (aborted)
P1 Trial 10/19 - 12/19
Bypass 12/6/19
Folfox + vecti 1/2/19 - 4/3/20
Kid Fail 5/1/20
Folfiri + Avastin 5/20 - 6/20
bypass 6/29/20
Stivarga 7/18/20 -
Home 9/10/20


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 4 guests