Exciting immune system research

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radnyc
Posts: 439
Joined: Tue Apr 06, 2010 6:32 pm

Exciting immune system research

Postby radnyc » Mon Jan 20, 2020 5:10 pm

Immune discovery 'may treat all cancer' https://www.bbc.co.uk/news/health-51182451
DX Jan '10, at 47
Feb - colon resection - 2/17 nodes
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April '11
HAI Pump removed Dec '15

Koreysue
Posts: 198
Joined: Mon Apr 30, 2018 2:36 pm

Re: Exciting immune system research

Postby Koreysue » Tue Jan 28, 2020 1:40 am

Very interesting!
Diagnosed: June 2017 stage 3 colon cancer
Sigmoid colon, 2 nodes affected
CEA at diagnosis: 6.1
Sigmoid Colectomy and folfox (chemo complete January 31, 2018)
CEA 4/2018: 2.4
CEA 7/2018: 3.7
Colonoscopy 8/2018 clean
PET scan 8/20/18 NED
CEA 11/2018: 3.8
CEA 2/2019: 3.2
CT NED 6/18/2019 / CEA : 3.4
CEA 10/21/19: 3.2
CEA 3/9/20: 3.8
CT NED /CEA 6/17/20: 3.8
CEA 11/4/20 4.6 <——— whyyyy? (will retest in a few weeks)
CT NED 12/1/20 CEA: 3.5 (happy to see a lower number)

Cured
Posts: 573
Joined: Thu Nov 27, 2008 10:53 pm
Location: MO

Re: Exciting immune system research

Postby Cured » Tue Jan 28, 2020 3:17 pm

We had also seen this story. It seems very realistic, as CAR-T has been working - just not for our solid tumors yet.
If we can be strong long enough for this to get tested and to market, this may be the cure for us.
5-08:Stg 3 Rectal: 6/14 Nodes
Ace Surgn Remvd 90%Rectm,lots of Colon-Full Incision
Ileo Rev'd 6 Mos.
Radiatn+5fu Pre-Surgery
FOLFOX 8 Cyc,1-09
Clear Scope 8-17; CEA 2-18
Glory to God! Healed by prayers of many: for 10 yrs
7-18: tumor pressing against brain Removed
Metastatic to lung. CEA 6.9
Folfiri
CEA 4.5 after 1 chemo
8rds CEA 3
CEA 1.8, 2.3,1.7,2.2,5.7,5.3,2.3.4.8,8.4,9.1,10
12 rd Folfiri
Avastin ev 2 wks
Seizure Anti-seiz meds work-no driving for 6m
4-20PET: Lng spots=Chemo
2-21 tumor gth =Folfiri

User avatar
CRguy
Posts: 10285
Joined: Sun Feb 10, 2008 6:00 pm

Re: Exciting immune system research

Postby CRguy » Tue Jan 28, 2020 10:07 pm

FYI
as both radnyc and Ehut had posted separate news releases about this,
I put a reference post into our Ongoing NEWS topic as well, listing the original paper
Immune discovery 'may treat all cancer'

I know this is still at the "mouse" stage... BUTT...
finding a commonality in our immune systems which could target all cancers
IS EXCITING !!!!

Cheers all
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
14 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

DAS43
Posts: 55
Joined: Thu Aug 18, 2016 8:10 pm

Re: Exciting immune system research

Postby DAS43 » Wed Jan 29, 2020 7:24 am

This sounds a lot like TIL research trial I had done at NIH. They just found a maker that may work better. I would think they could move to trying on humans pretty quickly since most of what they are doing has been done
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

sdino
Posts: 84
Joined: Tue Mar 28, 2017 5:32 pm

Re: Exciting immune system research

Postby sdino » Wed Jan 29, 2020 6:02 pm

Looks like Dr Rosenberg’s TIL trial at NIH. The TIL trial uses selected T-cells that express reactivity to your specific tumor mutations and are grown in the lab by the billions and replace your T-cells that don’t fight Cancer. This UK trial is same premis, but they appear to use all your T-cells because they ALL Express reactivity to cancers. It appears they deliver them via a virus. My Wife is in the TIL trial and is showing 23% shrinkage in her lung Mets and 95% reduction in her brain tumor and 2 lesions in the liver have shrunk 90% Last week. This was based on her 18 week follow up since her TIL infusion.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: 25+ Bilateral ranging 4mm-5.0cm
MSS, KRAS-G12D; TP53
iTCR TIL Trial NCT03412877 4/19 to 7/19 Off trial, - Sept. 2019 TIL trial NCT01174121
CT Scans: 7/2020 lung met shrinkage 36%, 3 lung mets left, two Liver mets destroyed by TILs
Brain tumor removal 3/2020
CEA:16-11/16; 5 -9/18; 63 -8/19; 1 -1/20; 0.8-5/20

Mrned82
Posts: 15
Joined: Wed Jan 08, 2020 6:38 am

Re: Exciting immune system research

Postby Mrned82 » Thu Jan 30, 2020 3:54 am

Promising!!!....hope....hope...hope!!!
male 37- italy/uk
stage 4 colon cancer with liver/lung mets since 2017
folfiri + cetuximab
7/2018 liver resection
09/2018 colon resection
38 rounds of chemo ...and still going on....
NO EXPIRATION DATE

I_will_fight
Posts: 72
Joined: Mon Jun 29, 2020 3:38 pm

Re: Exciting immune system research

Postby I_will_fight » Mon Jul 13, 2020 5:38 pm

radnyc wrote:Immune discovery 'may treat all cancer' https://www.bbc.co.uk/news/health-51182451


Thanks for sharing, very interesting, any recent research published on this?

Thank you

JC
46 yo male Spain
06/20 - 6cm T3N0M0 CC splenic flex
No liver mets, 3 and 4 mm lung dots (unlikely to be mets)
lymp 0/37
MSH6- other MMR+
KRAS mt G13D
V/LNI absent
PNI present
07/20 - hemicol surg, 13cm clear margins, optimistic surgn.
08/20 - CAPOX regime, 4 cycles.
11/20 - CAPOX completed. CAT scan: lesion in liver, suspect hemoangioma, no changes lung dots.
12/20 - Clean colonoscopy
02/21 - MRI liver lesion is nonspecific, stable.

brokenwings
Posts: 127
Joined: Mon Jan 07, 2019 1:50 am

Re: Exciting immune system research

Postby brokenwings » Tue Jul 14, 2020 3:25 pm

I haven't seen anything...
I follow several oncologists and advocates on Twitter... and I'm in several FB groups... Nothing there.
DX 2019 Adenocarcinoma Sigmoid colon. PC + ovarian met.
Obstruction. Temporary colostomy.
Folfirinox + Avastin: 6 cycles. Scans: partial response.
Surgery (CRS + HIPEC) 04/29: too much disease, surgery cancelled. Right ovary removed.
2nd ptotocol: IP chemo (oxaliplatin) + IV chemo (Folfiri + Avastin). 8 cycles
10/31/2019: 11 hour-long Hipec + 6 weeks in hospital
12/30/2019: liver met
02/05/2020: reversal surgery. New peri mets discovered
March 2020: 5fu+Avastin
May 2020: fistula
Back to 1957: 5fu.

NHMike
Posts: 2527
Joined: Fri Jul 21, 2017 3:43 am

Re: Exciting immune system research

Postby NHMike » Wed Jul 15, 2020 10:23 pm

DAS43 wrote:This sounds a lot like TIL research trial I had done at NIH. They just found a maker that may work better. I would think they could move to trying on humans pretty quickly since most of what they are doing has been done


My thought as well. The article is too simplified to make a determination on its usefulness and universality.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


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