Exciting immune system research

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radnyc
Posts: 434
Joined: Tue Apr 06, 2010 6:32 pm

Exciting immune system research

Postby radnyc » Mon Jan 20, 2020 5:10 pm

Immune discovery 'may treat all cancer' https://www.bbc.co.uk/news/health-51182451
DX Jan '10, at 47
Feb - colon resection - 2/17 nodes
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April '11
HAI Pump removed Dec '15

Koreysue
Posts: 153
Joined: Mon Apr 30, 2018 2:36 pm

Re: Exciting immune system research

Postby Koreysue » Tue Jan 28, 2020 1:40 am

Very interesting!
Diagnosed: June 2017 stage 3 colon cancer
Sigmoid colon, 2 nodes affected
CEA at diagnosis: 6
Sigmoid Colectomy and folfox (chemo complete January 31, 2018)
CEA 4/2018: 2.4
CEA 7/2018: 3.7
Colonoscopy 8/2018 clean
PET scan 8/20/18 NED (cea rise a mystery for now, doc said maybe all the smoke in my town from forest fires)
CEA 11/2018: 3.8
CEA 2/2019: 3.2
CT NED 6/18/2019 / CEA : 3.4
CEA 10/21/19: 3.2
CEA 3/9/20: 3.8
CT NED /CEA 6/17/20: 3.8

Cured
Posts: 561
Joined: Thu Nov 27, 2008 10:53 pm
Location: MO

Re: Exciting immune system research

Postby Cured » Tue Jan 28, 2020 3:17 pm

We had also seen this story. It seems very realistic, as CAR-T has been working - just not for our solid tumors yet.
If we can be strong long enough for this to get tested and to market, this may be the cure for us.
5-08:Stg 3 Rectal: 6/14 Nodes
Ace Surgn Remvd 90%Rectm,lots of Colon-Full Incision
Ileo Rev'd 6 Mos.
Radiatn+5fu Pre-Surgery
FOLFOX 8 CyclDone 1-09
Clear Scope 8-17; CEA 2-18
Glory to God! Healed by prayers of many: for 10 yrs
7-18: tumor pressing against brain Removed
Metastatic to lung. CEA 6.9
Folfiri
CEA to 4.5 after 1 chemo
After 8rds CEA 3
CEA 1.8, 2.3,1.7,2.2,5.7,5.3
12 rds Folfiri
Avastin evy 3 wks
Seizure Anti-seiz meds work-no driving for 6 mo
4-20PET: Lung spots=Chemo

User avatar
CRguy
Posts: 10179
Joined: Sun Feb 10, 2008 6:00 pm

Re: Exciting immune system research

Postby CRguy » Tue Jan 28, 2020 10:07 pm

FYI
as both radnyc and Ehut had posted separate news releases about this,
I put a reference post into our Ongoing NEWS topic as well, listing the original paper
Immune discovery 'may treat all cancer'

I know this is still at the "mouse" stage... BUTT...
finding a commonality in our immune systems which could target all cancers
IS EXCITING !!!!

Cheers all
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
13 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

DAS43
Posts: 55
Joined: Thu Aug 18, 2016 8:10 pm

Re: Exciting immune system research

Postby DAS43 » Wed Jan 29, 2020 7:24 am

This sounds a lot like TIL research trial I had done at NIH. They just found a maker that may work better. I would think they could move to trying on humans pretty quickly since most of what they are doing has been done
11/13 total blockage DX colon cancer IV, colostomy
1/14 folfox
3/14 liver resection NED
8/14 last chemo
12/14 colostomy reversal
8/16 3mets to lungs
10/16 trial at NIH TIL
9/17 partial responder to TIL protocol

sdino
Posts: 81
Joined: Tue Mar 28, 2017 5:32 pm

Re: Exciting immune system research

Postby sdino » Wed Jan 29, 2020 6:02 pm

Looks like Dr Rosenberg’s TIL trial at NIH. The TIL trial uses selected T-cells that express reactivity to your specific tumor mutations and are grown in the lab by the billions and replace your T-cells that don’t fight Cancer. This UK trial is same premis, but they appear to use all your T-cells because they ALL Express reactivity to cancers. It appears they deliver them via a virus. My Wife is in the TIL trial and is showing 23% shrinkage in her lung Mets and 95% reduction in her brain tumor and 2 lesions in the liver have shrunk 90% Last week. This was based on her 18 week follow up since her TIL infusion.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: Bilateral ranging 4mm-4.0cm
MSS, KRAS-G12D; TP53
Xeloda+Avastin 11/2016 to 2/2019
iTCR TIL Trial NCT03412877 4/19 to 7/19 Off trial, - Sept. 2019 TIL trial NCT01174121
CT Scans: 1/2020 lung met shrinkage 36%, Liver & Brain met shrinkage 90%
CEA:16-11/16; 5.1-9/18; 63.6-8/19; 1.2.9-1/20

Mrned82
Posts: 15
Joined: Wed Jan 08, 2020 6:38 am

Re: Exciting immune system research

Postby Mrned82 » Thu Jan 30, 2020 3:54 am

Promising!!!....hope....hope...hope!!!
male 37- italy/uk
stage 4 colon cancer with liver/lung mets since 2017
folfiri + cetuximab
7/2018 liver resection
09/2018 colon resection
38 rounds of chemo ...and still going on....
NO EXPIRATION DATE


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