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Looking for opinions or advice I guess.. (maybe just support)

Posted: Wed Jan 08, 2020 7:18 pm
by Monimom
My 56 y.o husband and I went to urgent care for a backache he had that wasn't going away, he does construction so we assumed it was work related, we left urgent care several hours later with the worst news, colonic mass with multiple liver lesions seen on CT scan
He was later sent for a PET scan that confirmed and then a liver biopsy to again confirm lesions were colon …and to do genetic testing, he does not have the kras mutation so he's eligible for other treatment types (I am just learning about ALL of this so if I say something incorrect i'm unaware, sorry)
He was told by the Hem/Oc Dr. he is inoperable due to the size and amounts of the liver lesions ...both lobes are involved and aside from many small both lobes have large lesions, one being 9cm..
his colon has what they referred to as an "apple core" type mass on his sigmoid colon I don't remember if they told us a size , he's not completely restricted and is still able to have bowel movements, not like he used to , but at least he's not blocked.
They said it doesn't appear to have spread elsewhere. So the game plan is to do chemo with hopes of shrinking tumors … maybe surgery if that happens otherwise chemo for life..(he said no way)
He has had the port put in his chest, and chemo has been started, we sit for 5 hours and then he wears a pump for 2 days , then it gets removed and in 2 weeks we do it again (im sure you're all familiar)
his first treatment went well, small amount of cold sensitivity from the Oxi that didn't last, and small tiredness .. they give him Decadron & Zofran then they start the treatment
it is the Folfox regimen with Oxaliplatin / Leucovorin (5fu ??)..
His second treatment (just finished today) they added Avastin to the mix.. he's had more of a stomach ache than before , don't know if its carry over hes had it off and on for a while ..or if the Avastin is adding to it, I am aware of the side affects of possible perforated bowel from Avastin so I am staying on top of his pain level temp/ etc..
we live in a small town , larger hopitals are an hour away, but they have all these satellite offices ..if that makes a difference is left to be seen.
So … a question for you would be.... does this all sound "typical?" as far as the way this is being managed ?
also for anyone with knowledge of the administration of Avastin... I have a question about dosage and infusion for the first time...message me if you do I wont waste space or time asking in this post.
Thank you if you read my post , I look forward to hearing back

Re: Looking for opinions or advice I guess.. (maybe just support)

Posted: Thu Jan 09, 2020 11:16 am
by AmyG
That sounds pretty typical, FOLFOX/Avastin mix for liver involvement.

For myself, I had my primary tumor removed first, then started chemo after I delivered my baby. I only had one liver met but responded wonderfully to the drugs.

Good luck with his treatment, I lost all my hair, eyebrows and lashes. Have pretty bad nerve damage in my hands and feet but I'm alive and cancer free!

Re: Looking for opinions or advice I guess.. (maybe just support)

Posted: Thu Jan 09, 2020 11:35 am
by Claudine
Welcome to the forum, it is a wonderful source of information and support! My husband just finished 18 rounds of Folfiri + Avastin (same protocol as yours, with the heavy infusion followed by 46 hours chemo pump). His situation is different (no liver involvement) but the goal was also tumor control (adrenal gland metastasis).
The main side effects of Avastin were digestive issues (really bad heart burn) and high blood pressure, so he's taking Omeprazole and blood pressure medication (I can't remember which). And since it's an anticoagulant, a little nosebleed (but not bad) - and he hasn't been able to get his teeth cleaned, but that's a pretty minor inconvenience!
Good luck to you and your husband, many folks on this forum who were inoperable at first had great responses to chemo and went on to having successful liver resections.