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***News Stories Thread*** ONGOING 2020

Posted: Wed Jan 01, 2020 3:35 am
by CRguy
To continue a great ColonTalk tradition ....... the 2020 NEWS topic !!!!!
AND in the words of its founder garbovatwin I will start things with the original intro from each year !!!!
Countdown to the Ongoing News Thread has begun.
May all YOUR news be GOOD.

For many of us, be it due to our busy schedules or our demanding treatment and surgeries, we can so easily miss out on a story that we could have/should have seen.

So, here you have it, an ONGOING News Thread where everyone can and probably should consider posting any news stories they deem important, RATHER than adding them to the general support topic thread, where they will clutter up and at times bury important posts for advice and support from fellow CRC members and family.

Please try to post THE LINK TO THE NEWS STORY ONLY to avoid any issues with re-posting copyrighted material.

Just click on the POST REPLY BUTTON
PASTE the link in the body of the post
PASTE the title in SUBJECT box

Good health and happiness to all.


Yet again, we thank you for all your work in keeping us up to date with recent events !
We have made this topic a "sticky" to keep it where everyone will know where to find it.

Once the year ends, we let the old News Topic float back down the page.
Previous ONGOING News Topics can be found here 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010

ALL Members please note that although garbovatwin has authored much of this topic... it is definitely for all members to use, so please keep it active, as instructed in the previous posting.

Best wishes to everyone for 2020



The following sites have proven to be reliable resources for cancer related information, much of which has appeared in this very topic !
Many of them will have "opt in" free account options so you may receive emails of any new releases or updates.
Some may have paid subscription options which members here need to review, if they need a more in depth focus.
( i.e. you can get the abstract from scientific papers with a free login BUTT need to pay to receive the whole article or publication. )

disclaimer : I use many of these sites regularly and receive their updates so I offer these links to share with ColonTalk members for their own specific needs and interests. I still think THIS forum = ColonTalk is the best general resource for anyone having to deal with the CRC Journey.
Members need to assess whether these links are suitable for their own purposes and can let us know if you have any problems with content or functionality.

Health Canada - recalls and alerts


U.S. cancer death rate drops by largest annual margin ever, report says

Posted: Sun Jan 12, 2020 11:52 pm
by JJH
U.S. cancer death rate drops by largest annual margin ever, report says
    That’s the largest drop ever seen in national cancer statistics going back to 1930, said Rebecca Siegel, the lead author. ... Experts mainly credit advances in treatment. Topping the list are refinements in surgery, better diagnostic scanning, and more precise use of radiation.

    They also celebrate the impact of newer drugs. Genetic testing can now identify specific cancer cell mutations, which allow more targeted therapy using newer pharmaceuticals that are a step beyond traditional chemotherapy.

    “It’s an exciting time,” said Dr. Jyoti Patel, a Northwestern University lung cancer expert. Even patients with late-stage cancers are surviving for several years — rather than months — after treatment starts, she said. “That was very, very uncommon a decade ago,” she said.
Full report:

Association of Acupuncture and Acupressure With Improved Cancer Pain

Posted: Mon Jan 13, 2020 9:05 pm
by CRguy
Association of Acupuncture and Acupressure With Improved Cancer Pain


Acupuncture has been used for symptomatic relief in patients with chronic pain related to cancer. This review evaluated existing data on the efficacy of this practice. In all, 14 randomized clinical trials with 920 patients were used in the meta-analysis. Real (compared with sham) acupuncture was associated with reduced pain intensity across the majority of studies. Furthermore, when combined with analgesics, acupuncture demonstrated utility in reducing pain intensity and reducing opioid use.
Further study is needed to see if acupuncture can be used as a part of a strategy to reduce opioid utilization in patients with cancer pain.

– Gautam Jayram, MD

Chili Pepper Consumption and Mortality in Italian Adults

Posted: Mon Jan 13, 2020 9:17 pm
by CRguy
Chili Pepper Consumption and Mortality in Italian Adults


This study examined the association between chili pepper consumption and mortality in a cohort of 22,811 Italian adults. Chili pepper intake was estimated by a food frequency questionnaire during the years 2005 to 2010. Over the course of a median 8.2 years of follow-up, there were 1236 deaths (5.4%). Those who regularly consumed chili peppers (more than four times/week) had lower all-cause mortality (multivariable HR, 0.77) and lower cardiovascular disease (CVD) mortality (multivariable HR, 0.66) compared with those who never or rarely consumed chili peppers. The effect appeared to be stronger in individuals without hypertension.
Regular consumption of chili peppers was associated with lower rates of total mortality and CVD mortality in a large population of Italian adults. The finding occurred independently of CVD risk factors or adherence to a Mediterranean diet.

Adverse Events Decreased With Proton Chemoradiotherapy

Posted: Mon Jan 13, 2020 9:20 pm
by CRguy
Adverse Events Decreased With Proton Chemoradiotherapy

Proton chemoradiotherapy is associated with a significantly lower risk for 90-day adverse events and a decrease in performance status during treatment compared with photon therapy, according to a study published online Dec. 26 in JAMA Oncology.

Leisure-Time Physical Activity Linked to Lower Cancer Risk

Posted: Mon Jan 13, 2020 9:23 pm
by CRguy
Leisure-Time Physical Activity Linked to Lower Cancer Risk

During follow-up, 50,620 incident cancers accrued. The researchers found that the risk for seven of the 15 cancers studied was significantly lower with engagement in recommended amounts of activity (7.5 to 15 metabolic equivalent task hours per week), including colon (8 to 14 percent lower in men), breast (6 to 10 percent lower risk), endometrial (10 to 18 percent lower risk), kidney (11 to 17 percent lower risk), myeloma (14 to 19 percent lower risk), liver (18 to 27 percent lower risk), and non-Hodgkin lymphoma (11 to 18 percent lower risk in women). For half of the associations, the dose response was linear and nonlinear for the others. For moderate- and vigorous-intensity leisure-time physical activity, the results were mixed.

Postoperative Oxaliplatin, 5-FU, and Leucovorin in Patients With Stage II or III Rectal Cancer Receiving Preoperative Ch

Posted: Mon Jan 13, 2020 9:25 pm
by CRguy
Postoperative Oxaliplatin, 5-FU, and Leucovorin in Patients With Stage II or III Rectal Cancer Receiving Preoperative Chemoradiation


This phase III trial evaluated adjuvant FOLFOX6 versus FOLFOX6 plus bevacizumab in patients with stage II or III rectal cancer who had undergone preoperative chemoradiation followed by definitive surgery.

There was no difference in 5-year overall survival between the two arms of the study. The addition of bevacizumab to FOLFOX6 in the adjuvant setting did not significantly improve overall survival in patients with stage II/III rectal cancer.

– Neil Majithia, MD

What are the odds of beating cancer?

Posted: Wed Jan 15, 2020 4:29 am
by JJH

When Life Throws You Curveballs, Embrace the ‘New Normal’

Posted: Mon Jan 20, 2020 11:59 pm
by JJH

recent articles of interest from Cancernetwork website

Posted: Sat Jan 25, 2020 12:34 pm
by CRguy

Immune discovery 'may treat all cancer'

Posted: Sun Jan 26, 2020 12:12 am
by CRguy
Following below is the original article referred to by 2 members who posted news releases on forum.

Immune discovery 'may treat all cancer'

British Scientists May Have Found Cure For Cancer. By Accident.

This IS very exciting news !
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Human leukocyte antigen (HLA)-independent, T cell–mediated targeting of cancer cells would allow immune destruction of malignancies in all individuals. Here, we use genome-wide CRISPR–Cas9 screening to establish that a T cell receptor (TCR) recognized and killed most human cancer types via the monomorphic MHC class I-related protein, MR1, while remaining inert to noncancerous cells. Unlike mucosal-associated invariant T cells, recognition of target cells by the TCR was independent of bacterial loading. Furthermore, concentration-dependent addition of vitamin B-related metabolite ligands of MR1 reduced TCR recognition of cancer cells, suggesting that recognition occurred via sensing of the cancer metabolome. An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma. These findings offer opportunities for HLA-independent, pan-cancer, pan-population immunotherapies.

Watch and Wait to Treat Rectal Cancer in Older Patients

Posted: Mon Jan 27, 2020 1:59 pm
by CRguy
Knowing what I know NOW .....
I would likely have accepted this option for my own situation !

Watch and Wait to Treat Rectal Cancer in Older Patients from PracticeUpdate

The authors evaluated the outcomes of 43 patients aged ≥75 years with at least 2 years of follow-up undergoing a watch-and-wait approach after a (near) clinical complete response following neoadjuvant treatment for rectal cancer. The 3-year local regrowth–free rate was 88%, and 3-year overall survival was 97%.

These findings support the consideration of this surgery-sparing approach in patients fitting this clinical scenario. Prospective studies are needed.

– Paul J. Hampel, MD

also available from the original journal : European Society of Surgical Oncology, which contains a list of very relevant references for those interested.

Is watch and wait a safe and effective way to treat rectal cancer in older patients?

The aim was assess the oncological and functional outcome of the watch-and-wait (W&W) approach in older patients with a clinical (near)complete response after neoadjuvant treatment for rectal cancer.

Material and methods
Patients were included in a W&W-approach (2004–2019) when digital rectal examination, endoscopy and MRI showed a (near)clinical complete response. Patients underwent endoscopy and MRI every 3 months during the first year, and 6-monthly thereafter. Patients aged ≥75 and ≥ 2 years of follow-up (FU) were selected. Oncological outcomes were assessed with Kaplan-Meier curves. Functional outcome was assessed with colostomy-free rate, Vaizey incontinence score, low anterior resection syndrome-score and International Prostate Syndrome Score.

43/304 (14%) of patients in a W&W-approach met the inclusion criteria. Median FU was 37 (24–109) months. 5/43(12%) developed a local regrowth. All were treated surgically, with one patient experiencing a pelvic failure. Distant metastases occurred in 3/43 patients and 4 patients died, 3 of whom not related to rectal cancer. The 3-year local regrowth-free rate was 88%, 3-year non-regrowth disease-free survival 91%, overall survival 97% and 3-year colostomy-free rate 93%. Overall, the bowel- and urinary dysfunction scores at 3, 12 and 24 months indicated good continence, no or minor LARS and moderate urinary problems.

W&W for older patients with a clinical (near) complete response appears to be a safe alternative to a total mesorectal excision (TME), with a very high pelvic control rate, and few rectal cancer related deaths. Most patients can avoid major surgery and a definitive colostomy, and have a reasonable anorectal and urinary function.

Re: Study Finds Racial Disparities in Timing and Type of Treatment in Colorectal Cancer Patients

Posted: Fri Feb 14, 2020 4:54 am
by JJH
Study Finds Racial Disparities in Timing and Type of Treatment in Colorectal Cancer Patients

    The findings suggest that the hospital capacity and availability of advanced technologies may benefit white patients, but not black patients, in terms of time-to-treatment and overall survival.

    • Factors related to size or capacity of the hospital were associated with colorectal tumor time-to-treatment and survival.

    • Racial disparities observed for time-to-treatment and survival associated with presence of treatment-related technologies

    • Presence of virtual colonoscopy was associated with lower likelihood of death.


Woman with rare parasite misdiagnosed with terminal liver cancer

Posted: Wed Feb 19, 2020 8:42 pm
by CRguy
Just a news bite to remind us ALL ...
just because we think it IS cancer...
it MAY NOT be and even her Docs missed it !

Woman with rare parasite misdiagnosed with terminal liver cancer