***News Stories Thread*** ONGOING 2020

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CRguy
Posts: 10245
Joined: Sun Feb 10, 2008 6:00 pm

2020 Immunotherapy updates

Postby CRguy » Sun Jul 12, 2020 1:09 pm

Caregiver x 4
Stage IV A rectal cancer/lung met
13 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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CRguy
Posts: 10245
Joined: Sun Feb 10, 2008 6:00 pm

Association of Treatment Adherence With Oncologic Outcomes for Patients With Rectal Cancer

Postby CRguy » Wed Jul 22, 2020 2:26 pm

TAKE-HOME MESSAGE

The authors of this post hoc analysis of a randomized phase III trial evaluated the impact of treatment adherence to neoadjuvant chemoradiotherapy and/or adjuvant chemotherapy on disease-free survival among 1232 patients with locally advanced rectal cancer. Complete adherence to neoadjuvant chemoradiotherapy compared with reduced adherence was associated with improved 3-year disease-free survival. However, complete versus incomplete adherence to adjuvant chemotherapy was not associated with disease-free survival.

Future trials should be designed to facilitate the delivery of optimal neoadjuvant chemoradiotherapy.

– Paul J. Hampel, MD


Association of Treatment Adherence With Oncologic Outcomes for Patients With Rectal Cancer

Beckster
Posts: 422
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Medications to Treat High Blood Pressure May Reduce Risk of Colorectal Cancer

Postby Beckster » Fri Aug 28, 2020 10:45 am

A recent study found a 22% lower risk in developing colorectal cancer in the 3 years after patients took hypertension medications to treat high blood pressure, heart failure, or heart disease.
https://www.cancernetwork.com/view/medi ... FpbC5jb20=
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda monotherapy
6/17,12/17,6/18,12/18, 6/19, 12/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0
Clear Colonoscopy 10/17, 11/19 :D

Beckster
Posts: 422
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Study Suggests PDE5 Inhibitors May Have Anti-Cancer Potential in Male Patients with CRC

Postby Beckster » Wed Oct 07, 2020 1:20 pm

Researchers suggested that potency enhancing phosphodiesterase-5 inhibitor drugs may have the ability to improve a prognosis in patients with colorectal cancer.
A study published in Nature Communications suggested that potency enhancing phosphodiesterase-5 (PDE5) inhibitor drugs, such as sildenafil (Viagra), have an anti-cancer potential with the ability to improve a prognosis in patients with colorectal cancer (CRC).


https://www.cancernetwork.com/view/stud ... FpbC5jb20=
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda monotherapy
6/17,12/17,6/18,12/18, 6/19, 12/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0
Clear Colonoscopy 10/17, 11/19 :D

Utwo
Posts: 270
Joined: Mon May 23, 2016 10:14 am
Location: T.O.

Scientists discovered that your outcome is better when you deal with a good rather than with a bad surgeon

Postby Utwo » Sun Nov 01, 2020 2:49 pm

58 yo male at diagnosis: T1bN0M0, 0/15 nodes, low grade/moderately differentiated adenocarcinoma
03/2016 colonoscopy: 2 small polyps removed in left colon; CEA = 1.3
04/2016 colonoscopy: caecum sessile 3.5 cm polyp piecemeal removed with kind of clear margins
05/2016 "prophylactic" laparoscopic right hemicolectomy - bleeding, leak, infection
06/2017 CT scan, colonoscopy OK; CEA = 1.6
A lot of funny stuff discovered by CT scans in liver, kidney, lungs, arteries, gallbladder, lymph node, pancreas

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Maggie Nell
Posts: 1142
Joined: Wed May 27, 2015 1:57 am
Location: Central Highlands, Victoria, Oz

Re: ***News Stories Thread*** ONGOING 2020

Postby Maggie Nell » Sun Nov 15, 2020 1:17 am

Be the change you want to see in the world........

https://www.abc.net.au/news/2020-11-15/ ... s/12876648

A statement of claim on behalf of Mr Whitehead has been lodged, alleging his treatment from both the Maryborough District Health Service and his former GP were negligent.

The document, lodged with the court in October, argues the alleged negligence had resulted in "injury, loss and damage", including the "progression of caecal adenocarcinoma, metastatic spread of adenocarcinoma, and reduced life expectancy".

"There is a difference between unlucky, and perhaps negligent, circumstances," Mr Whitehead's lawyer, Alice Robinson, said.



https://www.abc.net.au/news/2018-02-04/ ... er/9371386

Jodie Elisara first began suffering painful symptoms of bowel cancer in 2009, but another eight years would pass before doctors diagnosed the disease and began to treat it.


Ms Elisara, 36, said she noticed rectal bleeding, low iron levels and had extreme pain when passing stools, but her doctor told her it was haemorrhoids.

After multiple visits to three different GPs over the following years, the pain became unbearable.

"I went back to the doctors and said: 'You need to do something, even if it is haemorrhoids I want something done, I can't continue living like this'," she said.

Ms Elisara said she was eventually referred for a colonoscopy [...] in May 2015 but waited months on a list before having surgery for haemorrhoids in January 2017.

"That's when he [the doctor] told me that I actually had no haemorrhoids at all but I had a very large tumour in my colon," she said.

She was diagnosed with stage 3 bowel cancer.

"This case really stands out as an example of a young person really trying to do the right thing, but who has been terribly let down by the medical profession," Ms Atkinson said.
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r.j hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX

Sorbitol is the Devil
Ordained Dudeist Priest at Dudeism, the Church of the Latter-Day Dude 8)

I_will_fight
Posts: 45
Joined: Mon Jun 29, 2020 3:38 pm

Re: ***News Stories Thread*** ONGOING 2020

Postby I_will_fight » Sun Nov 15, 2020 4:50 am

Maggie Nell wrote:Be the change you want to see in the world........

https://www.abc.net.au/news/2020-11-15/ ... s/12876648

A statement of claim on behalf of Mr Whitehead has been lodged, alleging his treatment from both the Maryborough District Health Service and his former GP were negligent.

The document, lodged with the court in October, argues the alleged negligence had resulted in "injury, loss and damage", including the "progression of caecal adenocarcinoma, metastatic spread of adenocarcinoma, and reduced life expectancy".

"There is a difference between unlucky, and perhaps negligent, circumstances," Mr Whitehead's lawyer, Alice Robinson, said.



https://www.abc.net.au/news/2018-02-04/ ... er/9371386

Jodie Elisara first began suffering painful symptoms of bowel cancer in 2009, but another eight years would pass before doctors diagnosed the disease and began to treat it.


Ms Elisara, 36, said she noticed rectal bleeding, low iron levels and had extreme pain when passing stools, but her doctor told her it was haemorrhoids.

After multiple visits to three different GPs over the following years, the pain became unbearable.

"I went back to the doctors and said: 'You need to do something, even if it is haemorrhoids I want something done, I can't continue living like this'," she said.

Ms Elisara said she was eventually referred for a colonoscopy [...] in May 2015 but waited months on a list before having surgery for haemorrhoids in January 2017.

"That's when he [the doctor] told me that I actually had no haemorrhoids at all but I had a very large tumour in my colon," she said.

She was diagnosed with stage 3 bowel cancer.

"This case really stands out as an example of a young person really trying to do the right thing, but who has been terribly let down by the medical profession," Ms Atkinson said.



Thanks for this. This is something to keep in mind.

Sorry to digress, but I have one question regarding your signature, why is Sorbitol the devil? Is this CRC related or just general devility?
46 yo male at DX from Spain
June 2020 - 6 cm T3N0M0 cancer on left colon
No evidence of liver mets, two milimetric dots in lung, 3 and 4 mm (currently not considered mets)
lymph nodes 0/37
MSH6 non expressed, other MMR proteins present
KRAS mt G13D
Vascular invasion: absent
LNI: absent
PNI: present
July 8th 2020 - 50 cm colon and spleen removed, clean margins, optimistic surgeon.
Aug 2020 - start of XELOX regime, four cycles.

User avatar
Maggie Nell
Posts: 1142
Joined: Wed May 27, 2015 1:57 am
Location: Central Highlands, Victoria, Oz

Re: ***News Stories Thread*** ONGOING 2020

Postby Maggie Nell » Sun Nov 15, 2020 1:00 pm

I_will_fight wrote:
Sorry to digress, but I have one question regarding your signature, why is Sorbitol the devil? Is this CRC related or just general devility?


Eat a packet of sugar-free chewing gum and find out for yourself. :mrgreen:
DX April 2015, @ 54
35mm poorly diff. tumour, incidental finding following emergency r.j hemicolectomy
for ileo-colic intussusception.
Lymph nodes: 0/22
T3 N0 MX

Sorbitol is the Devil
Ordained Dudeist Priest at Dudeism, the Church of the Latter-Day Dude 8)


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