Regorafenib and Pembrolizumab

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meatie
Posts: 417
Joined: Wed Aug 20, 2014 8:13 am
Location: San Jose, CA

Regorafenib and Pembrolizumab

Postby meatie » Mon Dec 30, 2019 4:43 pm

Hi,
Is there any clinical trials /data on the use of Regorafenib and Pembrolizumab together on colon cancer patients?

meatie
Mother DX @59 8/14
cln+lvr res 9/14, stage 4
FOLOX+Avs 12-rd 10/14 to 4/15
Reoccurrence, KRAS mutant 11/15
Folfiri 18-rds 11/15-8/16
FOLFIRI with Ramicirumab 28-rds 8/17-9/18
Regorafenib 10/18-10/19
Lonsurf 10/19 onward

Claudine
Posts: 410
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Regorafenib and Pembrolizumab

Postby Claudine » Mon Dec 30, 2019 5:06 pm

Hi meatie,
I did a quick google search and this one popped up:

https://clinicaltrials.gov/ct2/show/NCT03657641
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 24.1
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: one 1mm stable nodule
PET 04/20 uptake by L4
L3-L4-L5 fusion surgery and residual tumor removal 05/20


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