I am sorry to read of what you guys are going through. It definitely sounds like a unique situation, one I have not read about often on this blog. The only suggestion I have is to seek an opinion from a major cancer center. Not sure where you guys are located and how close they are to you, but they have the most updated treatment plans to include chemo and radiation. The more information you share with them, the better the outcomes for treatment plans and next steps. I would assume there are regular protocols that need to still be exhausted prior to any clinical trials being in play. If you can share your general location, others can chime in here for suggestions for a second opinion too.
All the best.
D/H 47 years old, 10/2014, Stage IV M/CRC, nodes 12/15, para-aortic, 5 cm sigmoid resection, positive Virchow. KRAS mut, MSS, Highly Differentiated, Lynch Neg, 5FU/LV and Avastin 1 YR (Oxi for 5 months), Zeloda/Bev since 01/2016. 02/2019 recurrence para-nodes, back to 5FU/LV Oxy/Bev. It is working again. "...Perseverance is not a long race; it is many short races one after the other."-Walter Elliot