Postby hopefulandstrong » Tue Nov 19, 2019 11:47 am
As I scan the board, I notice that there are number of us who are seeing progression confined to the liver. I am BRAF and PPC3 positive, which means folfox and folfiri don't really work for me. Except maybe -- outside the liver. After three rounds of folfoxfiri, scans showed growth in the liver, but nowhere else, and some hot lymph nodes outside the liver were resolved. I'm told that we can have multiple mutations in different tumors. Wondering what it is about the liver that keeps the disease confined.
Any thoughts?
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)