DNA editing tool Crispr - can this be the one?

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radnyc
Posts: 439
Joined: Tue Apr 06, 2010 6:32 pm

DNA editing tool Crispr - can this be the one?

Postby radnyc » Mon Nov 11, 2019 8:16 pm

Let’s keep an eye on this trial, Crispr is in my opinion the best possibility for a cure at the moment. Only three patients have been recruited, very advanced cancers, seem to be stable. There’s still much to do.

https://www.nytimes.com/2019/11/06/heal ... -ios-share
DX Jan '10, at 47
Feb - colon resection - 2/17 nodes
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April '11
HAI Pump removed Dec '15

Siti
Posts: 209
Joined: Thu Aug 01, 2019 10:58 am

Re: DNA editing tool Crisp - can this be the one?

Postby Siti » Mon Nov 11, 2019 8:50 pm

Certainly looks promising! Really hope we’ll find a cure really soon :)
Wife of DH (54) DX on 5/7/19
Sigmoid | Adenocarcinoma | Grade: G3 | LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 7
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!! 20/12/19 Last round of Ox (NED)
1/2020 Maintenance: Cap + Avastin
4/2020 Maintenance: switch to Teysuno (S-1) + Avastin due to bad HFS side effects.

hopefulandstrong
Posts: 58
Joined: Fri Apr 19, 2019 7:11 pm

Re: DNA editing tool Crisp - can this be the one?

Postby hopefulandstrong » Mon Nov 11, 2019 9:02 pm

This seems similar to the NIH trial, yes? Similar approach to re-engineering cells to kill cancer cells?
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)

NHMike
Posts: 2527
Joined: Fri Jul 21, 2017 3:43 am

Re: DNA editing tool Crisp - can this be the one?

Postby NHMike » Tue Nov 12, 2019 9:33 am

hopefulandstrong wrote:This seems similar to the NIH trial, yes? Similar approach to re-engineering cells to kill cancer cells?


The NIH trials appear to be engineered cells. This approach seems more trial and error.

The article is horrible on the science, even getting the name and usage wrong.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


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