HELP! suspended treatment (nephrology)

Please feel free to read, share your thoughts, your stories and connect with others!
Marie25
Posts: 31
Joined: Tue Aug 20, 2019 9:32 am

HELP! suspended treatment (nephrology)

Postby Marie25 » Mon Nov 11, 2019 10:27 am

DH was scheduled for his 6th cycle today. Got a call from the local oncologist and between her and his nephrologist they have "suspended treatment untill further notice" In the meantime I know he will be enjoying his side effect free days but really hope it isn't put off longer than a week. They did this because his kidney function dropped since he began treatment. He went from kidney disease stage 3B to stage 4. Obviously I understand the concern and we don't want him in kidney failure but isn't the cancer worse.. we don't want that spreading either!! I'm not sure why they couldn't just lower the oxaliplatin again versus skipping treatment altogether. Does anyone know of chemo options that are totally safe for the kidneys? Any help is appreciated.
Supporter to my husband
Rectal adenocarcinoma
Folfox 8/2019
Short Course Radiation January 2020
Surgery January 2020
T3 N0 stage 2A
0/42 lymph nodes

e_enyedy
Posts: 29
Joined: Sat Nov 25, 2017 5:28 pm

Re: HELP! suspended treatment (nephrology)

Postby e_enyedy » Mon Nov 11, 2019 11:58 am

Unfortunately, Oxaliplatin is one of the least nephrotoxic chemo agent for CRC. I looked into this when I had renal issues caused by Avastin.
Perhaps you should ask your Oncologist.
77 yrs male (73 at Dx)
2/13 Dx Carcinoma, Sigmoid Colon
3/13 Sigmoid Colon Hemicolectomy,( 12"+)
3/13 Pathology Staging: T1N0M0; no follow-up chemo
5/15 Recurrence: in pre-sacral space -no other mets detected (Instantly became Stage IV)
5/15 Started 8 sessions of Folfox + Avastin
11/15 Finished chemo, PET/CT: NED
11/15 Started Xeloda+ Avastin every 3 weeks. Still Doing it.
Still NED -(Hope treatment keeps working)

Siti
Posts: 142
Joined: Thu Aug 01, 2019 10:58 am

Re: HELP! suspended treatment (nephrology)

Postby Siti » Mon Nov 11, 2019 12:08 pm

My husbands situation was a little different but the doctor delayed his second cycle by 1 week because he was hospitalised due to high fever and severe abdominal cramps. We were very concerned obviously but the doctor assured us that the delay doesn’t make a different in terms of effectiveness of the outcome but what’s more important is that he can tolerate the rest of the treatment.

What we did was proactively scheduled the next cycle exactly 1 week from the initial date even tough the hospital didn’t have a slot allocated. It gave us reassurance that there’s a date rather than just “delayed until further notice”.

I hope this helps.
Wife of DH (54) DX on 5/7/19
CEA value: 1.2
T loc: Sigmoid
T type: Adenocarcinoma
T grade: G3
Pos LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 9
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!!

Claudine
Posts: 301
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: HELP! suspended treatment (nephrology)

Postby Claudine » Mon Nov 11, 2019 12:35 pm

My husband's treatment has been delayed several times because of neutropenia, once by 2 weeks (so he went a month without treatment). It made absolutely no difference, his CEA levels stayed stable and cancer didn't progress :)
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin since 03/19
6.7 cm left adrenal mass 03/19, 3.67 cm 12/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 7.6
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: 2 calcified granulomas, one 1mm stable nodule

User avatar
ginabeewell
Posts: 405
Joined: Wed Oct 24, 2018 10:30 am

Re: HELP! suspended treatment (nephrology)

Postby ginabeewell » Mon Nov 11, 2019 1:26 pm

I think it’s very rare for someone to get all the way through 12 cycles without delay. I had low platelets for my 9th cycle and they didn’t recover a week later; ended up skipping that cycle because I had surgery scheduled a few weeks later. I was freaked out but it was fine.
45 year old mom of twins (8) and lucky stepmom of 14 and 16 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets
9/20/18 CEA 931
10/1/18 FOLFOX + Vectibix planned 12 rounds
12/12/18 CT scan showed typhlitis (7 days in hospital) but largest met down to 5 cm. Chemo holiday.
12/26/18 CEA 4.6
1/14/18 Resume chemo (#6-8)
3/27/19 HAI pump placement / colon resection
4/8/19 Resume chemo (#9-19) FOLFOX (no OX) + Vectibix
5/20/19 CEA 1.3
7/19/19 1st liver resection
10/16/19 2nd liver resection

natelaugh
Posts: 95
Joined: Wed Apr 03, 2019 11:40 pm

Re: HELP! suspended treatment (nephrology)

Postby natelaugh » Tue Nov 12, 2019 1:15 am

Have you try to ask to use only 5FU without oxaliplatin? My dad has kidney issues so nurse advise him to drink more water before blood test.

Nate.
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone

KimT
Posts: 686
Joined: Sat Feb 20, 2010 8:53 pm

Re: HELP! suspended treatment (nephrology)

Postby KimT » Tue Nov 12, 2019 8:35 am

Have they mentioned dialysis? In my experience as a nurse, stage 4 kidney disease requires dialysis. They may not be able to resume chemo until dialysis is begun.
2/10 dx colon cancer
right hemicolectomy 3/19/10
Stage 2a 0/43 nodes
Lynch syndrome
3/14/10 colon resection/ removal of metal clips
Nov 11 dx ovarian cancer

Marie25
Posts: 31
Joined: Tue Aug 20, 2019 9:32 am

Re: HELP! suspended treatment (nephrology)

Postby Marie25 » Tue Nov 12, 2019 9:35 am

KimT wrote:Have they mentioned dialysis? In my experience as a nurse, stage 4 kidney disease requires dialysis. They may not be able to resume chemo until dialysis is begun.



Nope, his nephrologist says dialysis is not needed untill stage 5, when the function is around 10%. he is in the high 20s. Also we would attempt to skip that altogether by me giving him one of my kidneys.
Supporter to my husband
Rectal adenocarcinoma
Folfox 8/2019
Short Course Radiation January 2020
Surgery January 2020
T3 N0 stage 2A
0/42 lymph nodes

Marie25
Posts: 31
Joined: Tue Aug 20, 2019 9:32 am

Re: HELP! suspended treatment (nephrology)

Postby Marie25 » Tue Nov 12, 2019 9:38 am

natelaugh wrote:Have you try to ask to use only 5FU without oxaliplatin? My dad has kidney issues so nurse advise him to drink more water before blood test.

Nate.



We will ask about doing that. Thank you!
Supporter to my husband
Rectal adenocarcinoma
Folfox 8/2019
Short Course Radiation January 2020
Surgery January 2020
T3 N0 stage 2A
0/42 lymph nodes


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Google [Bot] and 32 guests