Xeloda alone after allergic to Oxliplatin

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Suniva
Posts: 6
Joined: Mon Sep 30, 2019 4:03 pm

Xeloda alone after allergic to Oxliplatin

Postby Suniva » Tue Nov 05, 2019 4:59 pm

Hi,
As I husband get allergic to Oxliplatin, they stopped to give oxliplatin and just to have xeloda alone for a month. Is any one having xeloda alone without oxliplatina and working for colon cancer metastatic to lung?

Thank you
Diagnosed 10/2018 on sigmoid as stage 3C, and small nodules in right and left lungs.
11/2018 - laparoscopic surgery on colon
12/2018- 05/2019 xeloda two weeks on and one week off and oxiliplatin every 3rd weeks total 8th cycles.
05/2019- CT scan showed decreasing the nodules
08/2019- CT scan showed increasing the nodules (without any chemo)
09/2019- Done thoracotomy at right lung took two nodules, still nodule is left at left lung. Confirmed metastatic to lung.

Rock_Robster
Posts: 375
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Xeloda alone after allergic to Oxliplatin

Postby Rock_Robster » Tue Nov 05, 2019 5:08 pm

I had an allergic reaction to oxaliplatin (in FOLFOX) on my 8th infusion, so they switched me to irinotecan (FOLFIRI). Did they happen to mention why not go for this option?

Cheers
Rob
Male 37; Melbourne, Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+ PNI-
3 LN; 4 liver mets, resectable
pT3pN1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0
11/18 - FOLFOX x 6
3/19 - Liver resection
4-5/19 - 25 x pelvic radiation; complete met. response, TRG 3
07/19 - ULAR (robot), temp ileo, 1/27 LN
08/19 - Missed liver spot
08-11/19 - FOLFOX x 1, FOLFOXIRI x 1, FOLFIRI x 5
12/19 - Planned liver resection #2 & stoma reversal

User avatar
ginabeewell
Posts: 346
Joined: Wed Oct 24, 2018 10:30 am

Re: Xeloda alone after allergic to Oxliplatin

Postby ginabeewell » Tue Nov 05, 2019 9:52 pm

I’ve done 19 rounds of chemo, FOLFOX the first eight and then without the Oxi for the balance. I think that’s the chemical equivalent to Xeloda without Oxi?

Dr Kemeny was worried about having me on the Oxi too long, and I think she didn’t prescribe Iri because I had been having enough diarrhea issues with the Oxi. At the time I was also on Vectibix, and I think she figured it was working well enough that she didn’t need to introduce another agent to replace the Oxi.

I just had my second liver resection which showed 99% treatment response, so I guess her instincts were right!
45 year old mom of twins (8) and lucky stepmom of 14 and 16 year olds
9/17/18 DX stage 4 CRC w inoperable liver mets
9/20/18 CEA 931
10/1/18 FOLFOX + Vectibix planned 12 rounds
12/12/18 CT scan showed typhlitis (7 days in hospital) but largest met down to 5 cm. Chemo holiday.
12/26/18 CEA 4.6
1/14/18 Resume chemo (#6-8)
3/27/19 HAI pump placement / colon resection
4/8/19 Resume chemo (#9-19) FOLFOX (no OX) + Vectibix
5/20/19 CEA 1.3
7/19/19 1st liver resection
10/16/19 2nd liver resection

natelaugh
Posts: 83
Joined: Wed Apr 03, 2019 11:40 pm

Re: Xeloda alone after allergic to Oxliplatin

Postby natelaugh » Wed Nov 06, 2019 2:45 am

Suniva wrote:Hi,
As I husband get allergic to Oxliplatin, they stopped to give oxliplatin and just to have xeloda alone for a month. Is any one having xeloda alone without oxliplatina and working for colon cancer metastatic to lung?

Thank you

Hi Suniva,

My dad is currently taking Folfox which is similar to your regimen, but with addition of avastin. Avastin cuts off blood supply to the tumor. Also, the oncologist might suggest Folfiri, which has irinotecan. Before taking it, get a UGT1A1 gene test. "clinical significance in terms of tumor response or survival was not found according to UGT1A1 genotypes. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338934/

Nate.
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone

zephyr
Posts: 258
Joined: Thu Aug 18, 2016 7:31 am

Re: Xeloda alone after allergic to Oxliplatin

Postby zephyr » Thu Nov 07, 2019 7:44 pm

I'm Stage IV and on Xeloda and Avastin for a recurrence of lung mets. It's been keeping me stable.
Nov-2009 Early stage CRC found during routine colonoscopy
2010, 2011, 2014 Follow up colonoscopies, all clear
Jun-2016 CRC found during routine follow up colonoscopy, surgery, Stage 4, KRAS, MSS, inoperable lung mets
Aug-2016-May-2018 Folfox, 5FU & Avastin, 5FU, Folfiri & Cyramza
Aug/Sep-2018 YAG laser surgeries (Germany) on both lungs, 11 nodules (9 mets) removed
Nov-2018 clean CT scan
Mar-2019 New lung nodules
Apr/Jul-2019 Xeloda/Avastin, SBRT
Sept-2019 Stable! Continue Xeloda/Avastin

boxhill
Posts: 387
Joined: Fri Apr 06, 2018 11:40 am

Re: Xeloda alone after allergic to Oxliplatin

Postby boxhill » Fri Nov 08, 2019 1:18 pm

My dad is currently taking Folfox which is similar to your regimen, but with addition of avastin. Avastin cuts off blood supply to the tumor.


To clear up some possible confusion, FOLFOX is Oxy plus 5FU plus Leucovorin (which helps increase the effectiveness of 5FU, it is not a chemo drug on its own). It does not include Avastin, although some people, like your dad, take Avastin in addition.

As a side note, lots of people reduce or drop Oxy near the end of FOLFOX because of neuropathy.

Xeloda is the pill form of 5FU. *Most* of the effectiveness of FOLFOX comes from 5FU. Oxy definitely boosts it, but if you are allergic that may be a deal-breaker.

I know a few people who have successfully undergone a desensitization process with oxaliplatin after having a reaction to it. You should ask the oncologist about it, if you haven't already discussed it.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/4/18 FOLFOX
Neulasta 6/28
7/9/18 CT NED
11/20/18 CT NED. Enlarged spleen.
12/20/18 Liver MRI 5mm liver met? and 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/5/19 Triphasic CT LN and spleen normal, Liver node stable
6/28/19 Pause Keytruda, predisone for joint pain
7/31/19 Restart Keytruda
9/10/19 CT stable

natelaugh
Posts: 83
Joined: Wed Apr 03, 2019 11:40 pm

Re: Xeloda alone after allergic to Oxliplatin

Postby natelaugh » Fri Nov 08, 2019 10:35 pm

boxhill wrote:
My dad is currently taking Folfox which is similar to your regimen, but with addition of avastin. Avastin cuts off blood supply to the tumor.


To clear up some possible confusion, FOLFOX is Oxy plus 5FU plus Leucovorin (which helps increase the effectiveness of 5FU, it is not a chemo drug on its own). It does not include Avastin, although some people, like your dad, take Avastin in addition.

As a side note, lots of people reduce or drop Oxy near the end of FOLFOX because of neuropathy.

Xeloda is the pill form of 5FU. *Most* of the effectiveness of FOLFOX comes from 5FU. Oxy definitely boosts it, but if you are allergic that may be a deal-breaker.

I know a few people who have successfully undergone a desensitization process with oxaliplatin after having a reaction to it. You should ask the oncologist about it, if you haven't already discussed it.


Thank you for clearing it up. You are correct. My dad took a lower dose of the chemo, FOLFOX + Avastin. This is because we and the oncologist think a full dose might be too much, due to his age. Moreover, my dad will be doing 3 months of FOLFOX + avastin, then 2 months of 5FU + leucoverin + avastin, then repeat the 3 months of FOLFOX + Avastin.. etc...

Since 5FU + leucoverin didn't work for his adjuvant. We got a private CEA test for him after 1 cycle of FOLFOX + Avastin. His CEA dropped 38 to 35, which is not trending up. So, we are less concern about the regiment not working.

Thanks,
Nate.
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone


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