What, besides, tumor burden causes elevated CEA?

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hopefulandstrong
Posts: 53
Joined: Fri Apr 19, 2019 7:11 pm

What, besides, tumor burden causes elevated CEA?

Postby hopefulandstrong » Thu Oct 31, 2019 1:28 pm

I've searched the forum because I recall a couple of comments discussing things besides smoking that cause an elevated result -- things like dehydration, not enough/too much of one or another vitamin, general inflammation.... Can folks remind me of the list?
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)

Claudine
Posts: 165
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: What, besides, tumor burden causes elevated CEA?

Postby Claudine » Thu Oct 31, 2019 2:34 pm

I think I remember someone posting that his exercise regimen had an influence on the CEA levels.
Wife of Dx 04/2018 (51 yo). MSS, KRAS mutated G12A
No primary, lytic tumor L4 vertebrae, CEA 10
Radiation 04/2018
Resection small intestine 05/18 (no cancer found - Crohn's)
Xelox * 6, 05/2018 to 10/2018
6.7 cm left adrenal mass 03/14/2019, 4.4 cm 05/21, 4.1 cm 09/16
SBRT L4 02/2019
Folfiri + Avastin
CEA since 03/15: 58, then low of 3.2 now at 5.0 (twice)
Scan 03/14: Multiple small lung nodules
Scan 05/21: shrinking
Scan 09/16: lungs show no abnormalities (YAY!!!)

radnyc
Posts: 404
Joined: Tue Apr 06, 2010 6:32 pm

Re: What, besides, tumor burden causes elevated CEA?

Postby radnyc » Thu Oct 31, 2019 2:37 pm

Hi, your situation looks perfect for the HAI pump protocol, liver only mets, shrinking, have you enquirer?
DX Jan '10, at 47
Feb - colon resection - 2/17 nodes
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April '11
HAI Pump removed Dec '15

NHMike
Posts: 2302
Joined: Fri Jul 21, 2017 3:43 am

Re: What, besides, tumor burden causes elevated CEA?

Postby NHMike » Thu Oct 31, 2019 3:03 pm

Claudine wrote:I think I remember someone posting that his exercise regimen had an influence on the CEA levels.


That was me. My CEA chart had a correlation with my steps per day chart.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

Beckster
Posts: 397
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: What, besides, tumor burden causes elevated CEA?

Postby Beckster » Thu Oct 31, 2019 3:21 pm

A tooth abscess caused a sightly elevated CEA. Any inflammation or infection in the body can cause an elevated CEA. However, my onc said that you can take your CEA numerous times in one day and it will change.
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda monotherapy
6/17,12/17,6/18,12/18 6/19 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6
Clear Colonoscopy 10/17, 11/19 :D

hopefulandstrong
Posts: 53
Joined: Fri Apr 19, 2019 7:11 pm

Re: What, besides, tumor burden causes elevated CEA?

Postby hopefulandstrong » Thu Oct 31, 2019 3:27 pm

Super helpful. And yes, I am scheduled for pump placement in January. Assuming there is no spread outside the liver. There are a couple of lymph nodes (which I think is also accounting for CEA rise to 68) but Dr. Kingham says those come out along with the gall bladder. My procedure was postponed due to blood clots. I need to safely be off blood thinner for a bit before they can do surgery. In the meantime I'm doing Folfoxfiri, which is lower my liver enzymes, so I think it's working. We just to do everything we can to keep it from breaking out of the liver.

Fingers crossed!
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)

User avatar
Jacques
Posts: 534
Joined: Sun Dec 28, 2014 10:38 am
Location: Occitanie

Re: What, besides, tumor burden causes elevated CEA?

Postby Jacques » Thu Oct 31, 2019 9:59 pm

hopefulandstrong wrote:... Can folks remind me of the list?

Here's a list that you can look through to find other sources of elevated CarcinoEmbryonic Antigen (CEA):

https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=58961&p=465102#p465102

mpbser
Posts: 934
Joined: Wed Apr 19, 2017 11:52 am

Re: What, besides, tumor burden causes elevated CEA?

Postby mpbser » Mon Nov 04, 2019 5:55 am

My husband's CEA was recently 2.9 which was a jump from 2.2 three months ago. We were concerned until we read that hyperglycemia positively correlates with CEA. When my husband gets extremely stressed, e.g. morning of surgery, recent scanxiety on day of scan review during a time of enormous work stress, etc., his blood glucose goes through the roof. We believe that caused the relatively elevated CEA for him.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483971/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801242/
https://www.degruyter.com/downloadpdf/j ... 5-0002.pdf
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
low grade
1st primary T3 N2b M1a
Stage IVA
8/17 Sub-total colectomy
2nd primary 5.5 cm T1 N0
9 of 96 nodes
CEA: < 2.9
MSS
Lynch no; KRAS wild
Immunohistochemsistry Normal
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly bled to death
6-7 '19 5FU 4 cycles
NED


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