Promising new research

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Claudine
Posts: 355
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Promising new research

Postby Claudine » Tue Oct 08, 2019 10:59 am

A friend posted on FB regarding a new molecule called Glutor, that blocks a cancer cell’s ability to uptake and metabolize glucose and apparently works against 44 different cancers in vitro. I did a quick google search and this article popped up:
https://www.ncbi.nlm.nih.gov/pubmed/31303578
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 7.6
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: one 1mm stable nodule
PET 04/20 small uptake by L4
L3-L4-L5 fusion surgery and residual tumor removal 05/20

tater
Posts: 128
Joined: Wed Jul 19, 2017 5:53 pm

Re: Promising new research

Postby tater » Tue Oct 08, 2019 3:05 pm

I wonder where they are in the trial stages of it.
DH to 38 wife w/kids
Stage 3C DX 3/3/17 CEA 29
5-fu and radiation ended May 17, 2017
Stage 4 External iliac node July 17, 2017
FOLFOX + Avistan July 18 2017 CEA 2.3
Nov 9, 2017 Coloanal Anastomosis, Hysterectomy & External Nodes Removed W/ileostomy
Clear Margins NED
CEA 1.5 12/17, 2.1 2/18, 2.3 6/18, 1.1 9/18, 1.3 12/18, 1.8 3/19, 2.5 6/19
Clear CT and MRI on 2/5/2018, 9/18 Clear Scans
Reversal Surgery 6/26/18
Small Spot on right ureter surgery 10/30/19 adhered to artery
Dec. 2 start 12 rounds FOLFIRI

Claudine
Posts: 355
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Promising new research

Postby Claudine » Tue Oct 08, 2019 3:10 pm

I don't think they've reached that point yet... Still doing in vitro on cell cultures it seems.
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT radiation 04/18, SBRT 02/19
Resection small intestine 05/18 (no cancer found - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 7.6
Scan 03/19: Multiple small lung nodules up to 5mm
Scan 12/19: one 1mm stable nodule
PET 04/20 small uptake by L4
L3-L4-L5 fusion surgery and residual tumor removal 05/20

User avatar
GrouseMan
Posts: 836
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: Promising new research

Postby GrouseMan » Tue Oct 08, 2019 4:13 pm

The original paper cited in the Cell Chemical Biology journal they also used CB-839 which is a Glutaminase Inhibitor which may be found in 6 Clinical Trials mostly having to do with Lung Cancer. Its all promising work, but very early stages using this combination of GLUT-1, and GLUT-3 transporter inhibition by Glutor with CB-839. This is all related to the Warburg effect and how cancer cells utilize glucose.

Here are some additional references:
Warburg: https://en.wikipedia.org/wiki/Warburg_effect_(oncology)

The reference to the Cell Chemical Biology paper: https://www.sciencedirect.com/science/a ... 5619302065
The PubMed Reference: https://www.ncbi.nlm.nih.gov/pubmed/31303578

There is some discussion of this paper and fasting, and the Keto Diet here: https://www.acsh.org/news/2019/10/02/st ... mine-14314

Here is a reference to CB-839 clinical trials: https://www.cancer.gov/about-cancer/tre ... tor-cb-839
You should note that in this last there are two trials indicated that includes this drug in combinations with others that include patients with metastatic colon cancer.

Regards,

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

BIGC4ME
Posts: 8
Joined: Fri Jan 08, 2016 4:20 pm

Re: Promising new research

Postby BIGC4ME » Wed Oct 09, 2019 8:38 pm

This is great news for sure


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