Claudine wrote:Welcome helenef, hopefully this forum will be able to bring you as much comfort and useful information as it has others! I can't really answer your questions, but I read that Folforixi gives better results than Folfiri. Hopefully it'll shrink your tumor nicely and you can get surgery soon! Good luck with treatment.
MeAndMine wrote:My treatment is different for rectal cancer and I started out with radiation and chemo which I'm doing right now. It's also with the idea of shrinking the tumor. I don't really have the answers as I'm still new at all of this and on the first leg of my treatment but hopefully you'll get some good advice from others on the forum. I'm glad you found us!
NHMike wrote:Five hundred fifty-five patients who underwent surgery for primary colorectal cancer from January 2003 to December 2009 were analyzed for T3 subdivision. T3 subdivision was determined by the depth of invasion beyond the outer border of the proper muscle (T3a, <1 mm; T3b, 1 to 5 mm; T3c, >5 to 15 mm; T3d, >15 mm). We investigated the correlation between T3 subdivision and N, M staging and stage-independent prognostic factors including angiolymphatic invasion (ALI), venous invasion (VI) and perineural invasion (PNI).
I was curious about the results of the research too:
The tumors of the 555 patients were subclassified as T3a in 86 patients (15.5%), T3b in 209 patients (37.7%), T3c in 210 patients (37.8%) and T3d in 50 patients (9.0%). The nodal metastasis rates were 39.5% for T3a, 56.5% for T3b, 75.7% for T3c and 74.0% for T3d. The distant metastasis rates were 7.0% for T3a 9.1% for T3b, 27.1% for T3c and 40.0% for T3d. Both N and M staging correlated with T3 subdivision (Spearman's rho = 0.288, 0.276, respectively; P < 0.001). Other stage-independent prognostic factors correlated well with T3 subdivision (Spearman's rho = 0.250, P < 0.001 for ALI; rho = 0.146, P < 0.001 for VI; rho = 0.271, P < 0.001 for PNI).
Hmmm. I think that I had cT3 - maybe that's what the c is for - I have wondered about that for a while.
helenef wrote:I think c before TNM means clinical (from the scans and biopsies, before surgery). see here:
cTNM is based on all available information from:
The final stage is given after the evaluation of the pathology specimen, and is given prefix “p”. Pathological TNM (pTNM) is based on pT, pN and the apprehension of M (operation/ radiology).
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