How long oxilaplatin can be taken?

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Suniva
Posts: 4
Joined: Mon Sep 30, 2019 4:03 pm

How long oxilaplatin can be taken?

Postby Suniva » Wed Oct 02, 2019 1:59 pm

Hi, Did someone take oxilaplatin with xeloda, if yes how long does(how many cycle) this chemo is taken? Is there any worse side effect after it?
Diagnosed 10/2018 on sigmoid as stage 3C, and small nodules in right and left lungs.
11/2018 - laparoscopic surgery on colon
12/2018- 05/2019 xeloda two weeks on and one week off and oxiliplatin every 3rd weeks total 8th cycles.
05/2019- CT scan showed decreasing the nodules
08/2019- CT scan showed increasing the nodules (without any chemo)
09/2019- Done thoracotomy at right lung took two nodules, still nodule is left at left lung. Confirmed metastatic to lung.

Claudine
Posts: 131
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: How long oxilaplatin can be taken?

Postby Claudine » Wed Oct 02, 2019 3:34 pm

Hi Suniva,
My husband did 6 cycles of Xelox (oxaliplatin + Xeloda). Side effects (peripheral neuropathy) became really bad at the 5th treatment, and as adjuvant chemo it did not work anyway... Even if it had worked, I'm not sure how long he would have been able to take it because of the awful side effects. It's been a year since the last treatment and his feet are still pretty messed up (maybe permanently...)
Wife of Dx 04/2018 (51 yo). MSS, KRAS mutated G12A
No primary, lytic tumor L4 vertebrae, CEA 10
Radiation 04/2018
Resection small intestine 05/18 (no cancer found - Crohn's)
Xelox * 6, 05/2018 to 10/2018
6.7 cm left adrenal mass 03/14/2019, 4.4 cm 05/21, 4.1 cm 09/16
SBRT L4 02/2019
Folfiri + Avastin
CEA since 03/15: 58, 17, 10, 6.4, 5, 4.8, 4.2, 3.6, 3.2, 3.3, 3.2, 3.7, 4.3, 4.2, 4.2, 5.0
Scan 03/14: Multiple small lung nodules
Scan 05/21: shrinking
Scan 09/16: lungs show no abnormalities (YAY!!!)

Amarie123
Posts: 34
Joined: Wed Nov 14, 2018 6:46 am

Re: How long oxilaplatin can be taken?

Postby Amarie123 » Wed Oct 02, 2019 7:05 pm

I did 11 cycles of Oxaliplatin- though not with xeloda. I did 2 on FOLFOX and 9 on IROX (oxali+irinotecan). The neuropathy side effects were pretty intense in my hands and feet (moreso in my hands) during treatment. It’s been 3 months since I stopped and I do have some residual effects in my feet, but it’s tolerable. Everyone is different in how they’re effected so just keep doctors aware of the side effects throughout treatment so they can monitor you.

Mystimom
Posts: 5
Joined: Fri Mar 30, 2018 12:42 am

Re: How long oxilaplatin can be taken?

Postby Mystimom » Sun Oct 06, 2019 9:43 am

I did 12 cycles of FOLFOXIRI last year, and completed 5 out of another planned 12 this year due to liver recurrence...then moved to a new state, where my new onc took out the Ox, to stop my neuropathy from progressing, and just kept me on FOLOFIRI to complete the treatments.
I have tingling in my fingers, and the bottom of my feet fell like I'm walking in wet sand. It is tolerable though....but hasn't improved.

kandj
Posts: 261
Joined: Sun Sep 27, 2015 11:29 am

Re: How long oxilaplatin can be taken?

Postby kandj » Sun Oct 06, 2019 1:30 pm

My DH didn't do Oxaliplatin with Xeloda, but he did have Folfox and had 13 rounds of oxi( I think! may have been 11). Had to stop when he started having trouble swallowing and was choking due to neuropathy in his throat.

edited to add that the only residual side effects a few year later is some minor numbness in his feet.
wife to DH, dx 8/15 stage IV @36, numerous unresectable liver Mets
resection and HAI placed 12/15
Liver resection 5/19/2016 15-20 mets removed (surgeon lost count, but it hopeful he got it all!)
Recurrence 7/2017 4 Liver mets and one possible lung met
Radiation on liver Mets 12/17
Lung met 10/18
VATS on lung met 11/18 started xeloda
chemo break, nothing seen on scans 6/19 or 8/19 Hopeful

RichieTheK
Posts: 12
Joined: Mon May 29, 2017 11:27 am

Re: How long oxilaplatin can be taken?

Postby RichieTheK » Sun Oct 06, 2019 4:44 pm

I had 14 cycles of oxaliplatin as part of the FOLFOX regimen. The last 2 cycles were at reduced strength because of neuropathy. My neuropathy started after the 8th cycle. I saw a study where they recommended taking L-Glutamine while on oxaliplatin. I did so throughout my whole treatment.

Currently, I have tingling and slight numbness, but no neuropathic pain. Perhaps the L-Glutamine helped.

Rich
DX 5/13/2016 (Friday the 13th) mRCa Stage 4b
Met Liver, Lungs, Spine
mut KRAS G12V
mut PIK3CA
MSS
5/15/2016 Tumor partially obstructive; colostomy performed
5/2016 FOLFIRI with higher dose of Irinotecan
8/2017 Signs of tumor growth, added Avastin to FOLFIRI
4/16/2018 Primary tumor invading surrounding tissue. Chemo stopped
5/2018 Started radiation.
6/2018 Radiation finished
7/2018 Start FOLFOX
1/2019 FOLFOX canceled due to neuropathy after 14 cycles.
Maintenance, 5FU and Avastin
6/2019 FOLFIRI

Rock_Robster
Posts: 343
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: How long oxilaplatin can be taken?

Postby Rock_Robster » Sun Oct 06, 2019 7:51 pm

Hi Suniva,

A ‘standard’ full course of oxaliplatin is 12 cycles (24 weeks), but in trials typically around 80% of patients don’t make it this far - needing either a dose reduction or to change treatments due to side effects.

I did 6 cycles then had some delayed-onset neuropathy which almost fully resolved; I then did 3 more cycles and stopped due to an allergic reaction.

Indeed as Rich says there were some past studies suggesting that supplementing glutamine and calcium may be protective against neuropathy. I believe more recent research has suggested this may not be helpful however. There is also some weak suggestion that additional glutamine intake may promote tumour proliferation, so for this reason alone I’ve avoided it.

Good luck,
Rob
Male 37; Melbourne, Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+ PNI-
3 LN; 4 liver mets, resectable
pT3pN1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0
11/18 - FOLFOX x 6
3/19 - Liver resection
4-5/19 - 25 x pelvic radiation; complete met. response, TRG 3
07/19 - ULAR (robot), temp ileo, 1/27 LN
08/19 - Missed liver spot
08-11/19 - FOLFOX x 1, FOLFOXIRI x 1, FOLFIRI x 5
12/19 - Planned liver resection #2 & stoma reversal


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