Anybody heard of this trial? m3814 is a DNA-PK inhibitor that is supposed to make sure that cancer cells stay completely destroyed and don't repair their own DNA. It's a Phase 1B study to find out the highest dose that can be given along with chemoradiation. My radiation oncologist was very excited that I could be a candidate for the trial, but we haven't discussed in depth as I have only had one initial consultation. I've been trying to find the risks associated with m3814, but I haven't found anything yet.
Any insights or additional information is greatly appreciated. Thanks!
m3814 clinical trial
m3814 clinical trial
66 Female
7/15/19 Colonoscopy
7/26/19 DX: Rectal Adenocarcinoma
CEA 8/8/19-1.9, 12/6/19-2.3, 2/28/20-1.7, 11/27 - 1.9, 2/10/21 - 1.5
8/16/19 - 11/23/19 FOLFOX - 8 rounds
10/9 flex sig ~30% shrinkage 11/27/19-a bit more shrinkage
Neulasta 9/29/19, 10/27/19, 11/24/19
25 days Xeloda and radiation 12/17/2019 - 1/22/20
Robotic LAR 4/14/20 - clear margins - 0/15 nodes
Temp ileostomy - Reversal 7/15 - minor LARS
10/19/20 - clear colonoscopy
2/10/21 - clear CT
7/15/19 Colonoscopy
7/26/19 DX: Rectal Adenocarcinoma
CEA 8/8/19-1.9, 12/6/19-2.3, 2/28/20-1.7, 11/27 - 1.9, 2/10/21 - 1.5
8/16/19 - 11/23/19 FOLFOX - 8 rounds
10/9 flex sig ~30% shrinkage 11/27/19-a bit more shrinkage
Neulasta 9/29/19, 10/27/19, 11/24/19
25 days Xeloda and radiation 12/17/2019 - 1/22/20
Robotic LAR 4/14/20 - clear margins - 0/15 nodes
Temp ileostomy - Reversal 7/15 - minor LARS
10/19/20 - clear colonoscopy
2/10/21 - clear CT
Re: m3814 clinical trial
You may wish to read some of these listings,from a Google search, as there are a number of trials listed with chemo combinations as well.annieliz wrote:I've been trying to find the risks associated with m3814, but I haven't found anything yet.
m3814 clinical trial
this one gives some side effect info
Safety, clinical activity and pharmacological biomarker evaluation of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814:
https://clinicaltrials.gov/ will list other trials as well
Best wishes
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far
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