Colon tumor metastasis to pelvis

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Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 8:26 pm

Hi,

Is it unusual for metastatic Tumor not to shrink after after 5 chemo treatments
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Rock_Robster
Posts: 1027
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Colon tumor metastasis to pelvis

Postby Rock_Robster » Mon Sep 23, 2019 8:47 pm

Gloriamazz wrote:Hi,

Is it unusual for metastatic Tumor not to shrink after after 5 chemo treatments

Hi Gloriamazz, just to clarify - where is the the tumour you’re referring to located?
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Re: Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 11:51 pm

Hi

The tumor is an enlarging hypodense lesion in the left hemi pelvis differential diagnosis the left hemi pelvis posteriorly just medial to the post acetubulum,there is a 1.8 x 1.87 cm hypertensive lesion which previously measured 1.5

It didn’t grow but it didn’t shrink.

Thank you
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Re: Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 11:53 pm

I also had 5 treatments of pelvis radiation
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Rock_Robster
Posts: 1027
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Colon tumor metastasis to pelvis

Postby Rock_Robster » Tue Sep 24, 2019 1:16 am

Ok thanks gloriamazz. So from this description it sounds like the lesion is in the pelvic bone itself - is this correct? If this is the case then it may not respond to chemo as well as an organ with very good blood supply might, though radiation might normally be more effective. Perhaps others will have had some experience with this that they can help you with.

Have you had a PET scan either before or after treatment to confirm the metabolic activity level of the lesion?
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

claudine
Posts: 809
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Colon tumor metastasis to pelvis

Postby claudine » Tue Sep 24, 2019 11:23 am

Hi there Gloriamazz,
I will concur with Rock_Robster - if the met is a bone met, then my understanding is that chemo won't have a very big effect on it. Radiation - such as SBRT - seems to be more effective.
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary

Tumors: L4 04/18; left adrenal gland & small lung nodules 03/19
rectum 02/22 (pT3 pN0 stage 2A); L3 09/22

Surgeries: intestinal resect. 05/18 (no cancer - Crohn's); adrenalectomy 02/20
L3-L4-L5 fusion and corpectomy 05/20; LAR 04/22; ileo reversal 09/22
L2-L3 fusion and corpectomy 09/22

Treatments: EBRT 04/18; SBRT 02/19; Failed adjuvant Xelox ; Folfiri/Avastin 03/19 - 01/20
adjuvant chemorad (Xeloda) 06/22; SBRT 11/22; Xeloda/Avastin since 01/24


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