Colon tumor metastasis to pelvis

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Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 8:26 pm

Hi,

Is it unusual for metastatic Tumor not to shrink after after 5 chemo treatments
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Rock_Robster
Posts: 575
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Colon tumor metastasis to pelvis

Postby Rock_Robster » Mon Sep 23, 2019 8:47 pm

Gloriamazz wrote:Hi,

Is it unusual for metastatic Tumor not to shrink after after 5 chemo treatments

Hi Gloriamazz, just to clarify - where is the the tumour you’re referring to located?
39M Australia
2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1, Dec-20: 2.3, Mar-21=2.5, Jul-21=3.1
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (CT/PET/MRI/scope) - latest scans Jul-21

Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Re: Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 11:51 pm

Hi

The tumor is an enlarging hypodense lesion in the left hemi pelvis differential diagnosis the left hemi pelvis posteriorly just medial to the post acetubulum,there is a 1.8 x 1.87 cm hypertensive lesion which previously measured 1.5

It didn’t grow but it didn’t shrink.

Thank you
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Gloriamazz
Posts: 89
Joined: Thu Jul 12, 2018 1:59 pm
Facebook Username: gloriamazz@ yahoo.com
Location: Ohio
Contact:

Re: Colon tumor metastasis to pelvis

Postby Gloriamazz » Mon Sep 23, 2019 11:53 pm

I also had 5 treatments of pelvis radiation
June, scope
2.6 adenocarcinoma
8/8/18 APR
Stoma
March 19 CT 2 lung N.
April 29, 2019 Pelvis TMR 1.8 x 1.8 cm

7/22 - 7/29/ 2019 5 radi
no chemo 10 mo.
6-10-19 Folfox, Oxill
2nd Irinotecan , Folferi, FU5
12/14/2020, off folferi lung nods new
break going on pill drug Jan 2021
1/19/22, appt 2nd opinion wait to start Vectivix
2 mos no CHEMO
MMR
MSI/stable/HER2
1/2/2021 - round 1 Vectibix
Oligometastatic (NSCLC)

Rock_Robster
Posts: 575
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Colon tumor metastasis to pelvis

Postby Rock_Robster » Tue Sep 24, 2019 1:16 am

Ok thanks gloriamazz. So from this description it sounds like the lesion is in the pelvic bone itself - is this correct? If this is the case then it may not respond to chemo as well as an organ with very good blood supply might, though radiation might normally be more effective. Perhaps others will have had some experience with this that they can help you with.

Have you had a PET scan either before or after treatment to confirm the metabolic activity level of the lesion?
39M Australia
2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1, Dec-20: 2.3, Mar-21=2.5, Jul-21=3.1
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (CT/PET/MRI/scope) - latest scans Jul-21

Claudine
Posts: 538
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Colon tumor metastasis to pelvis

Postby Claudine » Tue Sep 24, 2019 11:23 am

Hi there Gloriamazz,
I will concur with Rock_Robster - if the met is a bone met, then my understanding is that chemo won't have a very big effect on it. Radiation - such as SBRT - seems to be more effective.
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: low 3.2, now 81.1
Scan 03/19: Multiple small lung nodules, now gone/calcified
PET 04/20 uptake by L4
L3-L4-L5 fusion surgery and partial corpectomy 05/20
Scan 06/17/2021: stable


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