Alpelisib--Anyone on this?

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hopefulandstrong
Posts: 58
Joined: Fri Apr 19, 2019 7:11 pm

Alpelisib--Anyone on this?

Postby hopefulandstrong » Mon Sep 16, 2019 8:21 am

Alpelisib is a relatively new treatment, which has gotten lots of positive press for its effectiveness with breast cancer. It seems to also have some efficacy in concert with BRAF inhibitors for folks who have both the BRAF and PIK3 mutation. Wondering if anyone here has any experience.

Thanks so much!
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)
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NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Alpelisib--Anyone on this?

Postby NHMike » Tue Sep 17, 2019 8:24 am

Could you post links to papers? I'd like to read a bit on this but I have to get to work.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT
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hopefulandstrong
Posts: 58
Joined: Fri Apr 19, 2019 7:11 pm

Re: Alpelisib--Anyone on this?

Postby hopefulandstrong » Tue Sep 17, 2019 11:29 am

Here are some papers related to Breast Cancer:

https://www.nejm.org/doi/full/10.1056/NEJMoa1813904

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114962/

https://www.fda.gov/drugs/resources-inf ... ast-cancer

And for CRC:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546207/

https://ascopubs.org/doi/abs/10.1200/JC ... suppl.3544
54, female
1/8/19 DS Stage 4 with Liver Mets; Successful Colon Resect
2/18/19 Started Folfox -- CEA 70
5/8/19 - BRAF mutation -- switch to Triplet Therapy: Encorafenib, Binimetinib, Cetximab
6/13/19 - CEA dropped from 214 to 22
8/29 - CEA jump to 30-- scans reveal liver spread, though still confined. triplet therapy abandoned; some concern about PIC3 mutation interfering with BRAF treatment
9/1 - 10/4 -- no treatment
10/4 -- folfoxfiri to stem further progression; pump placement in January (hopefully)
Top
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