Side effect question.

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Side effect question.

Postby Marie25 » Fri Sep 06, 2019 3:50 pm

When taking folfox is being cold a side effect? I know about the cold sensitivity in mouth, hands and feet. But was wondering if it also makes your whole body cold? Hopefully he isn't fighting an infection. It's only been 1 week since his first round. :cry:
Supporter to my husband
Rectal adenocarcinoma
Stage 3 T3N+
Folfox 8/2019
Short Course Radiation January 2020
Surgery January 2020

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Re: Side effect question.

Postby Claudine » Fri Sep 06, 2019 4:38 pm

Hi Marie,
My husband has always been a furnace (as in, he'd open all the windows because he was too hot and I would FREEZE!). But when he got on Xelox, he suddenly developed a full body cold sensitivity... So my take on it is that yes, oxaliplatin will make you much more susceptible to feeling the cold. That's why doing certain chemo regimens in winter is supposedly much worse than in the warm season.
Wife of Dx 04/2018 (51 yo). MSS, KRAS mutated G12A
No primary, lytic tumor L4 vertebrae, CEA 10
Radiation 04/2018
Resection small intestine 05/18 (no cancer found - Crohn's)
Xelox * 6, 05/2018 to 10/2018
6.7 cm left adrenal mass 03/14/2019, 4.4 cm 05/21, 4.1 cm 09/16
SBRT L4 02/2019
Folfiri + Avastin
CEA since 03/15: 58, then low of 3.2 now 6.9
Scan 03/14: Multiple small lung nodules
Scan 05/21: shrinking
Scan 09/16: lungs show no abnormalities (YAY!!!)

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Re: Side effect question.

Postby MetastaticEquilibria » Fri Sep 06, 2019 8:57 pm

I’ve had oxaliplatin and a bunch of other stuff, and my core body temperature seems to have permanently dropped. I used to be a furnace, with typical temp of 37 degrees or above when healthy. Now I’m at 35.5 when waking up, and never go above 37 unless I have a fever. Also feel colder in general.

I also lost a lot of weight, so how much of this was due to chemo is a bit hard to disentangle. But I also have permanently cold, half-numb feet now, I believe from oxaliplatin-induced neuropathy.
M55 Stage 4 Japan
12/16 Tumor rectal/sigmoid jct
1/17 Resect stage 2 T3N0M0+LVI
2-6/17 UFT+UZEL
7/17 Recurr.+2 liver mets stage 4
7-10/17 FOLFOX+Vectibix
11-12/17 FOLFOX+pelvic rad 60 Gy
1-7/18 FOLFOX+Vectibix
8-9/18 Liver protons 73 GyE
10-12/18 Xeloda+Avastin
2/19 New liver met
3/19 Liver protons 66 GyE
4/19 3 Lung mets
4-6/19 Vectibix
7-9/19 FOLFIRI+Cyramza
9/19 Biliary stent
10/19-now Lonsurf+Avastin
CEA 1.4-223 last 2: 130 74
CA19-9 2.8-232 last 2: 232 96
RAS wild MSS MET+ TP53-
UGT1A1*28 homo

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Re: Side effect question.

Postby Rock_Robster » Fri Sep 06, 2019 9:05 pm

Marie25 wrote:When taking folfox is being cold a side effect? I know about the cold sensitivity in mouth, hands and feet. But was wondering if it also makes your whole body cold? Hopefully he isn't fighting an infection. It's only been 1 week since his first round. :cry:

Do you mean cold as in he feels cold, or a lower than normal temperature?

I definitely feel the cold more since doing oxi, which I’m pretty sure is neuropathy-related. Wool-blend socks and gloves are my friend in winter.
Male 37; Melbourne, Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+ PNI-
3 LN; 4 liver mets
pT3pN1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0
11/18 - FOLFOX x 6
3/19 - Liver resection
4-5/19 - 25 x pelvic radiation; complete met. response
07/19 - ULAR (robot), temp ileo, 1/27 LN
08/19 - Missed liver spot
08-11/19 - FOLFOX x 1, FOLFOXIRI x 1, FOLFIRI x 5
12/19 - Planned liver resection #2 & (01/20) stoma reversal

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Re: Side effect question.

Postby boxhill » Fri Sep 06, 2019 10:43 pm

When I was on oxi I felt the cold in my feet and hands, but I didn't feel cold in general. I'm one of those people who is always hot. I find most spaces grossly overheated. There hasn't been any change in that. :)
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 nodes,5 mesentery nodes
5mm liver met out
pT3 pN2b pM1
BRAF wild, KRAS G12D
5/4/18 FOLFOX
Neulasta 6/28
7/9/18 CT NED
11/20/18 CT NED. Enlarged spleen.
12/20/18 Liver MRI 5mm liver met? and 2 lymph nodes in porta hepatis
12/31/18 Keytruda
6/5/19 Triphasic CT LN and spleen normal, Liver node stable
6/28/19 Pause Keytruda, predisone for joint pain
7/31/19 Restart Keytruda
9/10/19 CT stable

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Re: Side effect question.

Postby Jannine » Sat Sep 07, 2019 8:26 am

I had some odd side effects with FOLFOX, but with me it was mostly muscle twitches and muscle cramps in my hands and legs. I also had weird hair stuff (my hair quit falling out and stopped getting dirty, and has only recently started falling out at a normal rate, 9 months after finishing chemo). I don't know of anybody else who had anything like that. I expect there are a lot of side effects that aren't common.

I'd definitely mention it to his oncologist the next time he goes in for an infusion, even if it resolves before then.
DX: sigmoid colon cancer 5/2018. 48 F
laparoscopic sigmoid resection (24 cm removed); no stoma.
7.5cm adenocarcinoma -- mod. diff.
1 noncontiguous tumor deposit removed; 0/31 lymph nodes
T3 pN1c M0
5/18 before surgery, CEA 11.2
6/18 began FOLFOX
7/18: CEA 1.9; added neulasta post infusion
9/18: CEA 2.8
10/18: 25% chemo reduction
11/18: CEA 1.8
7/19 CT scan clear

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Re: Side effect question.

Postby margiej » Sat Sep 07, 2019 3:47 pm

I was very cold during chemo.. especially my extremities. Kept snuggled under an electric blanket a lot of the time. My feet are still cold all the time from the neuropathy, I am guessing.
Dx CC 12/2015, age 57 at Dx
Stage IIIb: T3N1b
Adenocarcinoma, sigmoid colon, 2.5 cm - low grade, moderately differentiated
3/6 positive lymph nodes
laparoscopic colectomy 1/20/2016
Capox started 3/4/16 - Six rounds
CT-suspicious lymph 2/22/16
PET scan 2/24/16 clear
CT 6/8/16 clear
Clear Colonoscopy 3/17
CT 10/3/17 clear
CT 10/17/18 clear
CEA 12/17 1.7
5/16 3.8
7/16 1.9
3/17 1.3
10/17 1.2
4/18 1.6
11/18 1.2

justin case
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Re: Side effect question.

Postby justin case » Wed Sep 11, 2019 5:49 pm

I live in south Texas, and 80 degrees is quite tolerable, at 72 degrees after Folfox, I put on a long sleeved garment !
7/11 diagnosed Stage 2 colon and rectal cancer
lar/temp ilio
Reversal & port removal
21 round of chemo Folfox 9tx, 5fu 12 tx
Last treatment July 2012

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