By visiting the website of Dr. Steven Roserberg’s lab of NCI today, I found he has another active TIL clinical trial that started last year in 2018 for solid tumors:
NCT03412877
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in People With Metastatic Cancer
This trial is different from the one where Celine got successful treatment:
NCT01174121
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
The key sentence in NCT03412877’s description that I like very much is:
“Recent studies have shown that these TIL predominantly recognize unique mutated neoantigens expressed by the cancer not shared by other melanomas.”
Does anyone have experience with or have more info about this new TIL trial?